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Concepts of extracellular matrix remodelling in tumour progression and metastasis
Nature communications, 2020-10, Vol.11 (1), p.1-19, Article 5120
[Peer Reviewed Journal]
The Author(s) 2020 ;ISSN: 2041-1723 ;EISSN: 2041-1723 ;DOI: 10.1038/s41467-020-18794-x ;PMID: 33037194
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Title:
Concepts of extracellular matrix remodelling in tumour progression and metastasis
Author:
Winkler, Juliane
;
Abisoye-Ogunniyan, Abisola
;
Metcalf, Kevin J.
;
Werb, Zena
Subjects:
Review
Is Part Of:
Nature communications, 2020-10, Vol.11 (1), p.1-19, Article 5120
Description:
Abstract Tissues are dynamically shaped by bidirectional communication between resident cells and the extracellular matrix (ECM) through cell-matrix interactions and ECM remodelling. Tumours leverage ECM remodelling to create a microenvironment that promotes tumourigenesis and metastasis. In this review, we focus on how tumour and tumour-associated stromal cells deposit, biochemically and biophysically modify, and degrade tumour-associated ECM. These tumour-driven changes support tumour growth, increase migration of tumour cells, and remodel the ECM in distant organs to allow for metastatic progression. A better understanding of the underlying mechanisms of tumourigenic ECM remodelling is crucial for developing therapeutic treatments for patients.
Publisher:
London: Nature Publishing Group UK
Language:
English
Identifier:
ISSN: 2041-1723
EISSN: 2041-1723
DOI: 10.1038/s41467-020-18794-x
PMID: 33037194
Source:
PubMed Central
ProQuest Central
DOAJ Directory of Open Access Journals
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