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Serum 25-Hydroxyvitamin D and Depressive Symptoms in Older Women and Men

The journal of clinical endocrinology and metabolism, 2010-07, Vol.95 (7), p.3225-3233 [Peer Reviewed Journal]

Copyright © 2010 by The Endocrine Society ;2015 INIST-CNRS ;Copyright © 2010 by The Endocrine Society 2010 ;ISSN: 0021-972X ;EISSN: 1945-7197 ;DOI: 10.1210/jc.2010-0347 ;PMID: 20444911 ;CODEN: JCEMAZ

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Title:
Serum 25-Hydroxyvitamin D and Depressive Symptoms in Older Women and Men
Author: Milaneschi, Yuri ; Shardell, Michelle ; Corsi, Anna Maria ; Vazzana, Rosamaria ; Bandinelli, Stefania ; Guralnik, Jack M ; Ferrucci, Luigi
Subjects: Affect ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Depression - blood ; Endocrinopathies ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; Geriatric Assessment ; Health Surveys ; Humans ; Italy ; Longitudinal Studies ; Male ; Medical sciences ; Original ; Proportional Hazards Models ; Psychiatric Status Rating Scales ; Risk Factors ; Surveys and Questionnaires ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vertebrates: endocrinology ; Vitamin D - analogs & derivatives ; Vitamin D - blood ; Vitamin D Deficiency - blood
Is Part Of: The journal of clinical endocrinology and metabolism, 2010-07, Vol.95 (7), p.3225-3233
Description: Context: Hypovitaminosis D and depressive symptoms are common conditions in older adults. Objective: We examined the relationship between 25-hydroxyvitamin D [25(OH)D] and depressive symptoms over a 6-yr follow-up in a sample of older adults. Design and Setting: This research is part of a population-based cohort study (InCHIANTI Study) in Tuscany, Italy. Participants: A total of 531 women and 423 men aged 65 yr and older participated. Main Outcome Measure: Serum 25(OH)D was measured at baseline. Depressive symptoms were assessed at baseline and at 3- and 6-yr follow-ups using the Center for Epidemiological Studies-Depression Scale (CES-D). Depressed mood was defined as CES-D of 16 or higher. Analyses were stratified by sex and adjusted for relevant biomarkers and variables related to sociodemographics, somatic health, and functional status. Results: Women with 25(OH)D less than 50 nmol/liter compared with those with higher levels experienced increases in CES-D scores of 2.1 (P = 0.02) and 2.2 (P = 0.04) points higher at, respectively, 3- and 6-yr follow-up. Women with low vitamin D (Vit-D) had also significantly higher risk of developing depressive mood over the follow-up (hazard ratio = 2.0; 95% confidence interval = 1.2–3.2; P = 0.005). In parallel models, men with 25(OH)D less than 50 nmol/liter compared with those with higher levels experienced increases in CES-D scores of 1.9 (P = 0.01) and 1.1 (P = 0.20) points higher at 3- and 6-yr follow-up. Men with low Vit- D tended to have higher risk of developing depressed mood (hazard ratio = 1.6; 95% confidence interval = 0.9–2.8; P = 0.1). Conclusion: Our findings suggest that hypovitaminosis D is a risk factor for the development of depressive symptoms in older persons. The strength of the prospective association is higher in women than in men. Understanding the potential causal pathway between Vit- D deficiency and depression requires further research. Hypovitaminosis D is a risk factor for the development of depressive symptoms in older persons.
Publisher: Bethesda, MD: Endocrine Society
Language: English
Identifier: ISSN: 0021-972X
EISSN: 1945-7197
DOI: 10.1210/jc.2010-0347
PMID: 20444911
CODEN: JCEMAZ
Source: GFMER Free Medical Journals
MEDLINE
Alma/SFX Local Collection

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Serum 25-Hydroxyvitamin D and Depressive Symptoms in Older Women and Men

Copyright © 2010 by The Endocrine Society ;2015 INIST-CNRS ;Copyright © 2010 by The Endocrine Society 2010 ;ISSN: 0021-972X ;EISSN: 1945-7197 ;DOI: 10.1210/jc.2010-0347 ;PMID: 20444911 ;CODEN: JCEMAZ

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