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Protein degradation-associated mechanisms that are affected in Alzheimer's disease

Molecular and cellular biochemistry, 2022-03, Vol.477 (3), p.915 [Peer Reviewed Journal]

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Title:
Protein degradation-associated mechanisms that are affected in Alzheimer's disease
Author: Tecalco-Cruz, Angeles C ; Pedraza-Chaverri, José ; Briones-Herrera, Alfredo ; Cruz-Ramos, Eduardo ; López-Canovas, Lilia ; Zepeda-Cervantes, Jesús
Subjects: Alzheimer's disease ; Medical research ; Medicine, Experimental ; Proteolysis ; Risk factors ; Ubiquitin
Is Part Of: Molecular and cellular biochemistry, 2022-03, Vol.477 (3), p.915
Description: Alzheimer's disease (AD) is the most common type of dementia associated with age-related neurodegeneration. Alteration of several molecular mechanisms has been correlated with the progression of AD. In recent years, dysregulation of proteostasis-associated pathways has emerged as a potential risk factor for neurodegenerative diseases. This review investigated the ubiquitin-proteasome system, lysosome-associated degradation, endoplasmic-reticulum-associated degradation, and the formation of advanced glycation end products. These pathways involved in proteostasis have been reported to be altered in AD, suggesting that their study may be critical for identifying new biomarkers and target molecules for AD.
Publisher: Springer
Language: English
Identifier: ISSN: 0300-8177
EISSN: 1573-4919
DOI: 10.1007/s11010-021-04334-8
Source: ProQuest Central

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