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Remodelling the extracellular matrix in development and disease

Nature reviews. Molecular cell biology, 2014-12, Vol.15 (12), p.786-801 [Peer Reviewed Journal]

COPYRIGHT 2014 Nature Publishing Group ;COPYRIGHT 2014 Nature Publishing Group ;Copyright Nature Publishing Group Dec 2014 ;Distributed under a Creative Commons Attribution 4.0 International License ;2014 Macmillan Publishers Limited. All rights reserved 2014 ;ISSN: 1471-0072 ;EISSN: 1471-0080 ;DOI: 10.1038/nrm3904 ;PMID: 25415508

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Title:
Remodelling the extracellular matrix in development and disease
Author: Bonnans, Caroline ; Chou, Jonathan ; Werb, Zena
Subjects: Animals ; Biochemistry, Molecular Biology ; Cellular control mechanisms ; Collagen ; Connective tissue ; Disease susceptibility ; Endopeptidases - metabolism ; Enzymes ; Epithelial Cells - chemistry ; Epithelial Cells - metabolism ; Extracellular matrix ; Extracellular Matrix - chemistry ; Extracellular Matrix - enzymology ; Extracellular Matrix - metabolism ; Extracellular Matrix - pathology ; Fibrosis - pathology ; Glycoproteins ; Growth factors ; Health aspects ; Humans ; Life Sciences ; Ligands ; Medical research ; Medicine, Experimental ; Morphogenesis ; Neoplasms - pathology ; Observations ; Proteins
Is Part Of: Nature reviews. Molecular cell biology, 2014-12, Vol.15 (12), p.786-801
Description: The extracellular matrix (ECM) is a highly dynamic structure that is present in all tissues and continuously undergoes controlled remodelling. This process involves quantitative and qualitative changes in the ECM, mediated by specific enzymes that are responsible for ECM degradation, such as metalloproteinases. The ECM interacts with cells to regulate diverse functions, including proliferation, migration and differentiation. ECM remodelling is crucial for regulating the morphogenesis of the intestine and lungs, as well as of the mammary and submandibular glands. Dysregulation of ECM composition, structure, stiffness and abundance contributes to several pathological conditions, such as fibrosis and invasive cancer. A better understanding of how the ECM regulates organ structure and function and of how ECM remodelling affects disease progression will contribute to the development of new therapeutics.
Publisher: England: Nature Publishing Group
Language: English
Identifier: ISSN: 1471-0072
EISSN: 1471-0080
DOI: 10.1038/nrm3904
PMID: 25415508
Source: AUTh Library subscriptions: ProQuest Central
Hyper Article en Ligne (HAL) (Open Access)
MEDLINE

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Remodelling the extracellular matrix in development and disease

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