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Triglyceride-Rich Lipoprotein Remnants and Cardiovascular Disease

Clinical chemistry (Baltimore, Md.), 2021-01, Vol.67 (1), p.183-196 [Peer Reviewed Journal]

American Association for Clinical Chemistry 2021. All rights reserved. For permissions, please email: journals.permissions@oup.com. 2021 ;American Association for Clinical Chemistry 2021. All rights reserved. For permissions, please email: journals.permissions@oup.com. ;COPYRIGHT 2021 American Association for Clinical Chemistry, Inc. ;ISSN: 0009-9147 ;EISSN: 1530-8561 ;DOI: 10.1093/clinchem/hvaa296 ;PMID: 33409533

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  • Title:
    Triglyceride-Rich Lipoprotein Remnants and Cardiovascular Disease
  • Author: Duran, Edward K ; Pradhan, Aruna D
  • Subjects: Analysis ; Arteriosclerosis ; Atherosclerosis ; Blood lipoproteins ; Cardiovascular diseases ; Cholesterol ; Chylomicrons ; Density ; Health risks ; Lipid metabolism ; Lipoproteins ; Lipoproteins (very low density) ; Medical research ; Medicine, Experimental ; Metabolism ; Packaging ; Physicochemical properties ; Prevention ; Proteolipids ; Triglycerides
  • Is Part Of: Clinical chemistry (Baltimore, Md.), 2021-01, Vol.67 (1), p.183-196
  • Description: Abstract Background Triglycerides, cholesterol, and their metabolism are linked due to shared packaging and transport within circulating lipoprotein particles. While a case for a causal role of cholesterol-carrying low-density lipoproteins (LDLs) in atherosclerosis is well made, the body of scientific evidence for a causal role of triglyceride-rich lipoproteins (TRLs) is rapidly growing, with multiple lines of evidence (old and new) providing robust support. Content This review will discuss current perspectives and accumulated evidence that an overabundance of remnant lipoproteins stemming from intravascular remodeling of nascent TRLs—chylomicrons and very low-density lipoproteins (VLDL)—results in a proatherogenic milieu that augments cardiovascular risk. Basic mechanisms of TRL metabolism and clearance will be summarized, assay methods reviewed, and pivotal clinical studies highlighted. Summary Remnant lipoproteins are rendered highly atherogenic by their high cholesterol content, altered apolipoprotein composition, and physicochemical properties. The aggregate findings from multiple lines of evidence suggest that TRL remnants play a central role in residual cardiovascular risk.
  • Publisher: England: Oxford University Press
  • Language: English
  • Identifier: ISSN: 0009-9147
    EISSN: 1530-8561
    DOI: 10.1093/clinchem/hvaa296
    PMID: 33409533
  • Source: AUTh Library subscriptions: ProQuest Central
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