Language:

Sex differences in biological aging with a focus on human studies

eLife, 2021-05, Vol.10 [Peer Reviewed Journal]

2021, Hägg and Jylhävä. ;COPYRIGHT 2021 eLife Science Publications, Ltd. ;2021, Hägg and Jylhävä. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2021, Hägg and Jylhävä 2021 Hägg and Jylhävä ;ISSN: 2050-084X ;EISSN: 2050-084X ;DOI: 10.7554/eLife.63425 ;PMID: 33982659

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Sex differences in biological aging with a focus on human studies
Author: Hagg, S ; Jylhava, J
Subjects: Age ; age-related diseases ; Aging ; Aging - pathology ; Aging - physiology ; Analysis ; Animals ; biological aging ; Biological clocks ; Biology ; Chromosomes ; Clinical trials ; Disease ; Epidemiology ; Epidemiology and Global Health ; Estrogens ; Female ; Females ; Free radicals ; Gender differences ; Gonadal Steroid Hormones - genetics ; Humans ; Male ; Medical research ; Medicin och hälsovetenskap ; Medicine, Experimental ; Metabolism ; Mutation ; Review ; Senescence ; Sex Characteristics ; Sex Chromosomes ; Sex differences ; Sexes ; Sexual dimorphism ; Steroids ; Theories of aging ; Womens health
Is Part Of: eLife, 2021-05, Vol.10
Description: Aging is a complex biological process characterized by hallmark features accumulating over the life course, shaping the individual's aging trajectory and subsequent disease risks. There is substantial individual variability in the aging process between men and women. In general, women live longer than men, consistent with lower biological ages as assessed by molecular biomarkers, but there is a paradox. Women are frailer and have worse health at the end of life, while men still perform better in physical function examinations. Moreover, many age-related diseases show sex-specific patterns. In this review, we aim to summarize the current knowledge on sexual dimorphism in human studies, with support from animal research, on biological aging and illnesses. We also attempt to place it in the context of the theories of aging, as well as discuss the explanations for the sex differences, for example, the sex-chromosome linked mechanisms and hormonally driven differences.
Publisher: England: eLife Science Publications, Ltd
Language: English
Identifier: ISSN: 2050-084X
EISSN: 2050-084X
DOI: 10.7554/eLife.63425
PMID: 33982659
Source: MEDLINE
PubMed Central
SWEPUB Freely available online
ROAD: Directory of Open Access Scholarly Resources
ProQuest Central
DOAJ Directory of Open Access Journals

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Sex differences in biological aging with a focus on human studies

Searching Remote Databases, Please Wait