skip to main content
Language:
Search Limited to: Search Limited to: Resource type Show Results with: Show Results with: Search type Index

Estimation and Application of Biological Variation of Urinary {delta}-Aminolevulinic Acid and Porphobilinogen in Healthy Individuals and in Patients with Acute Intermittent Porphyria

Clinical chemistry (Baltimore, Md.), 2006-04, Vol.52 (4), p.650 [Peer Reviewed Journal]

COPYRIGHT 2006 American Association for Clinical Chemistry, Inc. ;Copyright American Association for Clinical Chemistry Apr 2006 ;ISSN: 0009-9147 ;EISSN: 1530-8561 ;DOI: 10.1373/clinchem.2005.060772 ;PMID: 16595824

Full text available

Citations Cited by
  • Title:
    Estimation and Application of Biological Variation of Urinary {delta}-Aminolevulinic Acid and Porphobilinogen in Healthy Individuals and in Patients with Acute Intermittent Porphyria
  • Author: Aarsand, Aasne K ; Petersen, Per Hyltoft ; Sandberg, Sverre
  • Subjects: Care and treatment ; Medical research ; Medicine, Experimental ; Porphyria ; Porphyrins
  • Is Part Of: Clinical chemistry (Baltimore, Md.), 2006-04, Vol.52 (4), p.650
  • Description: Background: Diagnosis of an attack of acute intermittent porphyria (AIP) is based on the demonstration of increased concentrations of porphobilinogen (PBG) and [delta]-aminolevulinic acid (ALA) in urine, but many AIP patients also have high baseline concentrations in remission. The aim of this study was to estimate the biological variations of ALA, PBG, and porphyrins in healthy individuals and AIP patients to improve interpretation of test results. Methods: Fifteen healthy individuals and 15 AIP patients were included, and biological variations were calculated based on urine samples collected weekly for 10 consecutive weeks. For the AIP patients, long-term variations were also estimated based on 7 samples collected through a 2-year period. Results: The porphyrin variances were inhomogeneously distributed; biological variations of porphyrins were therefore not calculated. The within-subject biological variations of ALA and PBG were 16%-20% in the short-term settings and for PBG, 25% in the long-term setting, giving reference change values of ~50% and 70%, respectively. The probability of detecting a 100% real change in PBG was 97% in the short-term setting and 80% in the long-term setting. Conclusions: In an AIP patient, a 2-fold increase in PBG, independent of the baseline concentration, will be detected with a probability >80% and is most likely related to the patient's disease and not caused only by analytical and biological variation. When PBG is used in the assessment of AIP-related symptoms, both the PBG concentration in remission and the length of time since the previous sample must be considered.
  • Publisher: Washington: Am Assoc Clin Chem
  • Language: English
  • Identifier: ISSN: 0009-9147
    EISSN: 1530-8561
    DOI: 10.1373/clinchem.2005.060772
    PMID: 16595824
  • Source: ProQuest Central
Back to results list
Go to Previous pagePrevious Result  3 NextGo to Next page
INSPIRE LIBRARY - TON DUC THANG UNIVERSITY (84-028) 37 755 057 Feedback
19 Nguyen Huu Tho St. Dist.7, HCM thuvien@tdtu.edu.vn

Copyright © 2017 INSPIRE LIBRARY - TON DUC THANG UNIVERSITY

Searching Remote Databases, Please Wait