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Adaptive immunity-driven inflammation and cardiovascular disease

American journal of physiology. Heart and circulatory physiology, 2019-12, Vol.317 (6), p.H1254-H1257 [Peer Reviewed Journal]

Copyright American Physiological Society Dec 2019 ;ISSN: 0363-6135 ;EISSN: 1522-1539 ;DOI: 10.1152/ajpheart.00642.2019 ;PMID: 31702971

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Title:
Adaptive immunity-driven inflammation and cardiovascular disease
Author: Ilatovskaya, Daria V ; Halade, Ganesh V ; DeLeon-Pennell, Kristine Y
Subjects: Adaptive Immunity ; Animals ; Arteriosclerosis ; Atherosclerosis ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - immunology ; Cardiovascular Diseases - pathology ; Congestive heart failure ; Dendritic cells ; Homeostasis ; Humans ; Hypertension ; Immune response ; Immune system ; Immunity ; Immunity, Innate ; Inflammation ; Leukocytes (neutrophilic) ; Lymphocytes ; Lymphocytes B ; Lymphocytes T ; Macrophages ; Monocytes ; Phenotypes ; Physiology ; Reviews
Is Part Of: American journal of physiology. Heart and circulatory physiology, 2019-12, Vol.317 (6), p.H1254-H1257
Description: The adaptive immune response has recently emerged as an important factor in a wide variety of cardiovascular disorders including atherosclerosis, hypertension, cardiac remodeling, and heart failure; however, its role is not fully understood. Since an assortment of innate responsive cells, e.g., neutrophils and monocytes/macrophages, coordinate with adaptive immunity, e.g., T cells, dendritic cells, and B cells, the temporal response and descriptions pertinent to the cellular phenotype and inflammation processes, in general, need additional investigation, clarification, and consensus particularly in cardiovascular disease. This Perspectives article reviews the contributions of 15 articles (including 7 reviews) published in the in response to the Call for Papers: Adaptive Immunity in Cardiovascular Disease. Here, we summarize the crucial reported findings at the cardiac, vascular, immune, and molecular levels and discuss the translational feasibility and benefits of future prospective research into the adaptive immune response. Readers are encouraged to evaluate the data and learn from this collection of novel studies.
Publisher: United States: American Physiological Society
Language: English
Identifier: ISSN: 0363-6135
EISSN: 1522-1539
DOI: 10.1152/ajpheart.00642.2019
PMID: 31702971
Source: GFMER Free Medical Journals
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Adaptive immunity-driven inflammation and cardiovascular disease

Copyright American Physiological Society Dec 2019 ;ISSN: 0363-6135 ;EISSN: 1522-1539 ;DOI: 10.1152/ajpheart.00642.2019 ;PMID: 31702971

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