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New roles of aldosterone and mineralocorticoid receptors in cardiovascular disease: translational and sex-specific effects

American journal of physiology. Heart and circulatory physiology, 2018-10, Vol.315 (4), p.H989-H999 [Peer Reviewed Journal]

Copyright American Physiological Society Oct 2018 ;Copyright © 2018 the American Physiological Society 2018 American Physiological Society ;ISSN: 0363-6135 ;EISSN: 1522-1539 ;DOI: 10.1152/ajpheart.00073.2018 ;PMID: 29957022

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Title:
New roles of aldosterone and mineralocorticoid receptors in cardiovascular disease: translational and sex-specific effects
Author: Davel, Ana Paula ; Jaffe, Iris Z ; Tostes, Rita C ; Jaisser, Frederic ; Belin de Chantemèle, Eric J
Subjects: Age Factors ; Aging ; Aldosterone ; Aldosterone - metabolism ; Animals ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - drug therapy ; Cardiovascular Diseases - immunology ; Cardiovascular Diseases - metabolism ; Cardiovascular Diseases - physiopathology ; Cardiovascular System - drug effects ; Cardiovascular System - immunology ; Cardiovascular System - metabolism ; Cardiovascular System - physiopathology ; Chronic illnesses ; Congresses as Topic ; Epithelial cells ; Female ; Gender aspects ; Homeostasis ; Humans ; Hypertension ; Immune system ; Immunosuppressive agents ; Injury prevention ; Ischemia ; Kidney - drug effects ; Kidney - metabolism ; Kidney - physiopathology ; Leptin ; Ligands ; Male ; Mineralocorticoid Receptor Antagonists - therapeutic use ; Mineralocorticoid receptors ; Muscles ; Obesity ; Receptors ; Receptors, Mineralocorticoid - drug effects ; Receptors, Mineralocorticoid - metabolism ; Renal function ; Reperfusion ; Review ; Sex ; Sex differences ; Sex Factors ; Signal Transduction ; Smooth muscle ; Translation ; Translational Medical Research ; Vascular diseases
Is Part Of: American journal of physiology. Heart and circulatory physiology, 2018-10, Vol.315 (4), p.H989-H999
Description: Recent advances in the field of mineralocorticoid receptor (MR) and its ligand aldosterone expanded the role of this hormone and its receptor far beyond their initial function as a regulator of Na and K homeostasis in epithelial cells. The symposium "New Roles of Aldosterone and Mineralocorticoid Receptors in Cardiovascular Disease: Translational and Sex-Specific Effects" presented at the 38th World Congress of the International Union of Physiological Sciences (Rio de Janeiro, Brazil) highlighted the contribution of extrarenal MRs to cardiovascular disease. This symposium showcased how MRs expressed in endothelial, vascular smooth muscle, and immune cells plays a critical role in the development of vascular disease associated with aging, obesity, and chronic aldosterone stimulation and demonstrated that MR antagonism prevents the acute renal dysfunction and tubular injury induced by ischemia-reperfusion injury. It was also shown that the adipocyte-derived hormone leptin is a new direct regulator of aldosterone secretion and that leptin-mediated aldosterone production is a major contributor to obesity-associated hypertension in women. Sex differences in the role of aldosterone and of endothelial MR in the cardiovascular outcomes of obesity were highlighted. This review summarizes these important emerging concepts regarding the contribution of aldosterone and cell-specific MR to cardiovascular disease in male and female subjects and further supports sex-specific benefits of MR antagonist drugs to be tested in additional populations.
Publisher: United States: American Physiological Society
Language: English
Identifier: ISSN: 0363-6135
EISSN: 1522-1539
DOI: 10.1152/ajpheart.00073.2018
PMID: 29957022
Source: GFMER Free Medical Journals
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New roles of aldosterone and mineralocorticoid receptors in cardiovascular disease: translational and sex-specific effects

Copyright American Physiological Society Oct 2018 ;Copyright © 2018 the American Physiological Society 2018 American Physiological Society ;ISSN: 0363-6135 ;EISSN: 1522-1539 ;DOI: 10.1152/ajpheart.00073.2018 ;PMID: 29957022

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