Language:

Cellular senescence links aging and diabetes in cardiovascular disease

American journal of physiology. Heart and circulatory physiology, 2018-09, Vol.315 (3), p.H448-H462 [Peer Reviewed Journal]

Copyright American Physiological Society Sep 2018 ;ISSN: 0363-6135 ;EISSN: 1522-1539 ;DOI: 10.1152/ajpheart.00287.2018 ;PMID: 29750567

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Cellular senescence links aging and diabetes in cardiovascular disease
Author: Shakeri, Hadis ; Lemmens, Katrien ; Gevaert, Andreas B ; De Meyer, Guido R Y ; Segers, Vincent F M
Subjects: Aging ; Aging - metabolism ; Animals ; Arteriosclerosis ; Atherosclerosis ; Bioavailability ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - etiology ; Cardiovascular Diseases - metabolism ; Cell cycle ; Cellular Senescence ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus - etiology ; Diabetes Mellitus - metabolism ; Health risks ; Heart diseases ; Heart failure ; Humans ; Inflammation ; Nitric oxide ; Oxidative stress ; Phenotypes ; Risk analysis ; Risk factors ; Senescence
Is Part Of: American journal of physiology. Heart and circulatory physiology, 2018-09, Vol.315 (3), p.H448-H462
Description: Aging is a powerful independent risk factor for cardiovascular diseases such as atherosclerosis and heart failure. Concomitant diabetes mellitus strongly reinforces this effect of aging on cardiovascular disease. Cellular senescence is a fundamental mechanism of aging and appears to play a crucial role in the onset and prognosis of cardiovascular disease in the context of both aging and diabetes. Senescent cells are in a state of cell cycle arrest but remain metabolically active by secreting inflammatory factors. This senescence-associated secretory phenotype is a trigger of chronic inflammation, oxidative stress, and decreased nitric oxide bioavailability. A complex interplay between these three mechanisms results in age- and diabetes-associated cardiovascular damage. In this review, we summarize current knowledge on cellular senescence and its secretory phenotype, which might be the missing link between aging and diabetes contributing to cardiovascular disease.
Publisher: United States: American Physiological Society
Language: English
Identifier: ISSN: 0363-6135
EISSN: 1522-1539
DOI: 10.1152/ajpheart.00287.2018
PMID: 29750567
Source: GFMER Free Medical Journals
MEDLINE
Alma/SFX Local Collection

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Cellular senescence links aging and diabetes in cardiovascular disease

Copyright American Physiological Society Sep 2018 ;ISSN: 0363-6135 ;EISSN: 1522-1539 ;DOI: 10.1152/ajpheart.00287.2018 ;PMID: 29750567

Searching Remote Databases, Please Wait