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A role for collagen type IV in cardiovascular disease?

American journal of physiology. Heart and circulatory physiology, 2018-09, Vol.315 (3), p.H610-H625 [Peer Reviewed Journal]

Copyright American Physiological Society Sep 2018 ;ISSN: 0363-6135 ;EISSN: 1522-1539 ;DOI: 10.1152/ajpheart.00070.2018 ;PMID: 29677463

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Title:
A role for collagen type IV in cardiovascular disease?
Author: Steffensen, L B ; Rasmussen, L M
Subjects: Animals ; Arteries ; Arteriosclerosis ; Atherosclerosis ; Basement membranes ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - genetics ; Cardiovascular Diseases - metabolism ; Chromosome 13 ; Collagen ; Collagen (type IV) ; Collagen Type IV - genetics ; Collagen Type IV - metabolism ; Collagens ; Coronary artery ; Coronary artery disease ; Genes ; Genomes ; Health risks ; Heart diseases ; Humans ; Loci ; Membranes ; Mutation ; Polymorphism, Single Nucleotide ; Single-nucleotide polymorphism ; Stiffening
Is Part Of: American journal of physiology. Heart and circulatory physiology, 2018-09, Vol.315 (3), p.H610-H625
Description: Over the past decade, studies have repeatedly found single-nucleotide polymorphisms located in the collagen ( COL) 4A1 and COL4A2 genes to be associated with cardiovascular disease (CVD), and the 13q34 locus harboring these genes is one of ~160 genome-wide significant risk loci for coronary artery disease. COL4A1 and COL4A2 encode the α - and α -chains of collagen type IV, a major component of basement membranes in various tissues including arteries. Despite the growing body of evidence indicating a role for collagen type IV in CVD, remarkably few studies have aimed to directly investigate such a role. The purpose of this review is to summarize the clinical reports linking 13q34 to coronary artery disease, atherosclerosis, and artery stiffening and to assemble the scattered pieces of evidence from experimental studies based on vascular cells and tissue collectively supporting a role for collagen type IV in atherosclerosis and other macrovascular disease conditions.
Publisher: United States: American Physiological Society
Language: English
Identifier: ISSN: 0363-6135
EISSN: 1522-1539
DOI: 10.1152/ajpheart.00070.2018
PMID: 29677463
Source: GFMER Free Medical Journals
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A role for collagen type IV in cardiovascular disease?

Copyright American Physiological Society Sep 2018 ;ISSN: 0363-6135 ;EISSN: 1522-1539 ;DOI: 10.1152/ajpheart.00070.2018 ;PMID: 29677463

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