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Pathogenic arterial remodeling: the good and bad of microRNAs

American journal of physiology. Heart and circulatory physiology, 2013-04, Vol.304 (8), p.H1050-H1059 [Peer Reviewed Journal]

Copyright American Physiological Society Apr 15, 2013 ;ISSN: 0363-6135 ;EISSN: 1522-1539 ;DOI: 10.1152/ajpheart.00267.2012 ;PMID: 23396454 ;CODEN: AJPPDI

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Title:
Pathogenic arterial remodeling: the good and bad of microRNAs
Author: Wei, Yuanyuan ; Schober, Andreas ; Weber, Christian
Subjects: Aneurysm - genetics ; Aneurysm - immunology ; Aneurysm - pathology ; Arteries - immunology ; Arteries - pathology ; Arteries - physiopathology ; Atherosclerosis - genetics ; Atherosclerosis - immunology ; Atherosclerosis - pathology ; Cardiovascular disease ; Cardiovascular Diseases - genetics ; Cardiovascular Diseases - immunology ; Cardiovascular Diseases - pathology ; Cell growth ; Cell Proliferation ; Endothelial Cells - pathology ; Gene expression ; Gene Expression Regulation - immunology ; Gene Expression Regulation - physiology ; Humans ; Inflammation - genetics ; Inflammation - immunology ; Inflammation - pathology ; Macrophages - immunology ; Macrophages - pathology ; MicroRNAs - immunology ; MicroRNAs - physiology ; Muscle, Smooth, Vascular - immunology ; Muscle, Smooth, Vascular - pathology ; Muscle, Smooth, Vascular - physiopathology ; Myocytes, Smooth Muscle - pathology ; Pathogenesis ; Physiology ; Ribonucleic acid ; RNA
Is Part Of: American journal of physiology. Heart and circulatory physiology, 2013-04, Vol.304 (8), p.H1050-H1059
Description: A number of cardiovascular diseases, such as restenosis, aneurysm, and atherosclerosis, lead to vascular remodeling associated with complex adaptive reactions of different cell populations. These reactions include growth of smooth muscle cells, proliferation of endothelial cells, and the inflammatory response of macrophages. MicroRNAs (miRNAs), a class of short RNAs, play key roles in various biological processes and in the development of human disease by post-transcriptional regulation of gene expression. Here, we review the molecular mechanisms of a subset of miRNAs involved in vascular remodeling, including miR-143/145, miR-221/222, miR-126, miR-21, and miR-155. Some of these miRNAs, such as miR-143/145 and miR-126, have been shown to be protective during vascular remodeling, whereas others, such as miR-21, may promote the cellular response that leads to neointima formation. The increasing knowledge regarding the roles of miRNAs in vascular remodeling opens novel avenues for the treatment of various cardiovascular diseases. However, more in vivo studies on the functional roles of these miRNAs are required in the future.
Publisher: United States: American Physiological Society
Language: English
Identifier: ISSN: 0363-6135
EISSN: 1522-1539
DOI: 10.1152/ajpheart.00267.2012
PMID: 23396454
CODEN: AJPPDI
Source: GFMER Free Medical Journals
MEDLINE
Alma/SFX Local Collection

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Pathogenic arterial remodeling: the good and bad of microRNAs

Copyright American Physiological Society Apr 15, 2013 ;ISSN: 0363-6135 ;EISSN: 1522-1539 ;DOI: 10.1152/ajpheart.00267.2012 ;PMID: 23396454 ;CODEN: AJPPDI

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