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Kinetic analysis of the kappa agonist tracer [11C]GR103545 in healthy controls

NeuroImage (Orlando, Fla.), 2010-08, Vol.52 (S1), p.S172-S172 [Peer Reviewed Journal]

2010 ;Copyright Elsevier Limited Aug 1, 2010 ;ISSN: 1053-8119 ;EISSN: 1095-9572 ;DOI: 10.1016/j.neuroimage.2010.04.140

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  • Title:
    Kinetic analysis of the kappa agonist tracer [11C]GR103545 in healthy controls
  • Author: Tomasi, Giampaolo ; Zheng, Ming ; Ropchan, Jim ; Weinzimmer, David ; Linn, Shu-Fei ; Nabulsi, Nabeel ; Williams, Wendol ; Ding, Yu-Shin ; Jacobsen, Leslie ; Huang, Henry ; Carson, Richard
  • Subjects: Estimates
  • Is Part Of: NeuroImage (Orlando, Fla.), 2010-08, Vol.52 (S1), p.S172-S172
  • Description: Following reconstruction with motion correction and registration to an MR template, regional TACs were generated and fitted to the 1T and 2T models, with the metabolite-corrected input function, to estimate VT for each ROI. Test/retest variability in regions with higher BPND with the arterial input function should be sufficient for an occupancy study which targets high occupancy; improved quantification strategies, however, will be important for the application of [11C]GR103545 in clinical populations.
  • Publisher: Amsterdam: Elsevier Inc
  • Language: English
  • Identifier: ISSN: 1053-8119
    EISSN: 1095-9572
    DOI: 10.1016/j.neuroimage.2010.04.140
  • Source: ProQuest One Psychology
    Alma/SFX Local Collection
    ProQuest Central
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