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Plasmodium-associated changes in human odor attract mosquitoes

Proceedings of the National Academy of Sciences - PNAS, 2018-05, Vol.115 (18), p.E4209-E4218 [Peer Reviewed Journal]

Volumes 1–89 and 106–114, copyright as a collective work only; author(s) retains copyright to individual articles ;Copyright National Academy of Sciences May 1, 2018 ;2018 ;Wageningen University & Research ;ISSN: 0027-8424 ;EISSN: 1091-6490 ;DOI: 10.1073/pnas.1721610115 ;PMID: 29666273

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Title:
Plasmodium-associated changes in human odor attract mosquitoes
Author: Robinson, Ailie ; Busula, Annette O. ; Voets, Mirjam A. ; Beshir, Khalid B. ; Caulfield, John C. ; Powers, Stephen J. ; Verhulst, Niels O. ; Winskill, Peter ; Muwanguzi, Julian ; Birkett, Michael A. ; Smallegange, Renate C. ; Masiga, Daniel K. ; Mukabana, W. Richard ; Sauerwein, Robert W. ; Sutherland, Colin J. ; Bousema, Teun ; Pickett, John A. ; Takken, Willem ; Logan, James G. ; de Boer, Jetske G.
Subjects: Aldehydes ; Animals ; Anopheles - physiology ; Antennae ; Aquatic insects ; Attraction ; Biological Sciences ; Biomarkers ; Child ; Child, Preschool ; Children ; Culicidae ; Disease biomarkers ; Disease transmission ; Female ; Host attractiveness ; Humans ; Malaria ; Malaria - metabolism ; Malaria - transmission ; Male ; Mimicry ; Mosquito Vectors - physiology ; Mosquitoes ; Odorants ; Odors ; Parasites ; Parasite–vector–host interactions ; Plasmodium ; Plasmodium - metabolism ; PNAS Plus ; Vector-borne diseases ; Vectors
Is Part Of: Proceedings of the National Academy of Sciences - PNAS, 2018-05, Vol.115 (18), p.E4209-E4218
Description: Malaria parasites (Plasmodium) can change the attractiveness of their vertebrate hosts to Anopheles vectors, leading to a greater number of vector–host contacts and increased transmission. Indeed, naturally Plasmodium-infected children have been shown to attract more mosquitoes than parasite-free children. Here, we demonstrate Plasmodium-induced increases in the attractiveness of skin odor in Kenyan children and reveal quantitative differences in the production of specific odor components in infected vs. parasite-free individuals. We found the aldehydes heptanal, octanal, and nonanal to be produced in greater amounts by infected individuals and detected by mosquito antennae. In behavioral experiments, we demonstrated that these, and other, Plasmodium-induced aldehydes enhanced the attractiveness of a synthetic odor blend mimicking “healthy” human odor. Heptanal alone increased the attractiveness of “parasite-free” natural human odor. Should the increased production of these aldehydes by Plasmodium-infected humans lead to increased mosquito biting in a natural setting, this would likely affect the transmission of malaria.
Publisher: United States: National Academy of Sciences
Language: English
Identifier: ISSN: 0027-8424
EISSN: 1091-6490
DOI: 10.1073/pnas.1721610115
PMID: 29666273
Source: GFMER Free Medical Journals
MEDLINE
PubMed Central

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Plasmodium-associated changes in human odor attract mosquitoes

Volumes 1–89 and 106–114, copyright as a collective work only; author(s) retains copyright to individual articles ;Copyright National Academy of Sciences May 1, 2018 ;2018 ;Wageningen University & Research ;ISSN: 0027-8424 ;EISSN: 1091-6490 ;DOI: 10.1073/pnas.1721610115 ;PMID: 29666273

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