skip to main content
Language:
Search Limited to: Search Limited to: Resource type Show Results with: Show Results with: Search type Index

Emerging Roles of Xenobiotic Detoxification Enzymes in Metabolic Diseases

DOI: 10.1515/reveh-2016-0050

Digital Resources/Online E-Resources

Citations Cited by
  • Title:
    Emerging Roles of Xenobiotic Detoxification Enzymes in Metabolic Diseases
  • Author: Petriello, Michael C ; Hennig, Bernhard ; Morris, Andrew J ; Hoffman, Jessie B
  • Subjects: cardiovascular disease ; dioxin ; Environmental Health and Protection ; FMO3 ; Medical Pathology ; metabolic pathologies ; Nutritional and Metabolic Diseases ; TMAO
  • Description: Mammalian systems have developed extensive molecular mechanisms to protect against the toxicity of many exogenous xenobiotic compounds. Interestingly, many detoxification enzymes, including cytochrome P450s and flavin-containing monooxygenases, and their associated transcriptional activators [e.g. the aryl hydrocarbon receptor (AhR)], have now been shown to have endogenous roles in normal physiology and the pathology of metabolic diseases. This mini-review will focus on two such instances: the role of flavin-containing monooxygenase 3 (FMO3) in the formation of the cardiometabolic disease biomarker trimethylamine-N-oxide (TMAO) and the role of AhR as a sensor of endogenous ligands such as those generated by the gut microbiota. Understanding the roles of xenobiotic sensing pathways in endogenous metabolism will undoubtedly lead to a better understanding of how exposure to environmental pollutants can perturb these physiological processes.
    Published in Reviews on Environmental Health, v. 32, issue 1-2, p. 105-110. ©2017 Walter de Gruyter GmbH, Berlin/Boston. The copyright holder has granted the permission for posting the article here.
  • Creation Date: 2017
  • Language: English
  • Identifier: DOI: 10.1515/reveh-2016-0050
  • Source: UKnowledge
Back to results list
INSPIRE LIBRARY - TON DUC THANG UNIVERSITY (84-028) 37 755 057 Feedback
19 Nguyen Huu Tho St. Dist.7, HCM thuvien@tdtu.edu.vn

Copyright © 2017 INSPIRE LIBRARY - TON DUC THANG UNIVERSITY

Searching Remote Databases, Please Wait