Language:

Mutant Cohesin in Premature Ovarian Failure

The New England journal of medicine, 2014-03, Vol.370 (10), p.943-949 [Peer Reviewed Journal]

Copyright © 2014 Massachusetts Medical Society. All rights reserved. ;2015 INIST-CNRS ;Distributed under a Creative Commons Attribution 4.0 International License ;Copyright © 2014 Massachusetts Medical Society 2014 ;ISSN: 0028-4793 ;EISSN: 1533-4406 ;DOI: 10.1056/NEJMoa1309635 ;PMID: 24597867 ;CODEN: NEJMAG

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Mutant Cohesin in Premature Ovarian Failure
Author: Caburet, Sandrine ; Arboleda, Valerie A ; Llano, Elena ; Overbeek, Paul A ; Barbero, Jose Luis ; Oka, Kazuhiro ; Harrison, Wilbur ; Vaiman, Daniel ; Ben-Neriah, Ziva ; García-Tuñón, Ignacio ; Fellous, Marc ; Pendás, Alberto M ; Veitia, Reiner A ; Vilain, Eric
Subjects: Animals ; Biochemistry, Molecular Biology ; Biological and medical sciences ; Cell Cycle Proteins ; Cell Cycle Proteins - genetics ; Chromosomal Proteins, Non-Histone ; Chromosomal Proteins, Non-Histone - genetics ; Chromosome 7 ; Chromosome deletion ; Cohesin ; Cohesins ; Disease Models, Animal ; Diseases of mother, fetus and pregnancy ; Female ; Fetuses ; Frameshift mutation ; Gene deletion ; Gene mutations ; General aspects ; Genetic aspects ; Genetics ; Gynecology and obstetrics ; Gynecology. Andrology. Obstetrics ; Human health and pathology ; Humans ; Infertility ; Infertility, Female ; Infertility, Female - genetics ; Life Sciences ; Medical sciences ; Meiosis ; Mice ; Miscarriage ; Mutation ; Nuclear Proteins ; Nuclear Proteins - genetics ; Oocytes ; Pedigree ; Pregnancy. Fetus. Placenta ; Primary Ovarian Insufficiency ; Primary Ovarian Insufficiency - genetics ; Prophase ; Reproductive status ; Reproductive system ; Risk factors ; Womens health
Is Part Of: The New England journal of medicine, 2014-03, Vol.370 (10), p.943-949
Description: Few genes have been implicated in sporadic premature ovarian failure. This study implicates STAG3, which encodes a cohesin, a protein that mediates chromosome pairing during meiosis. Premature ovarian failure, the end point of primary ovarian insufficiency, affects approximately 1% of women worldwide. Patients with premature ovarian failure present with at least a 6-month history of amenorrhea and elevated plasma levels of follicle-stimulating hormone (>40 mIU per milliliter). The disorder can result from premature depletion of the follicle pool, follicular atresia, follicle growth arrest, or ovarian dysgenesis. Although a majority of cases are idiopathic, premature ovarian failure can be caused by infectious agents, chemotherapy, pelvic surgery, autoimmune disease, environmental factors, or genetic conditions. 1 The disorder is observed in syndromic diseases — for example, Turner's syndrome and BPES . . .
Publisher: Waltham, MA: Massachusetts Medical Society
Language: English
Identifier: ISSN: 0028-4793
EISSN: 1533-4406
DOI: 10.1056/NEJMoa1309635
PMID: 24597867
CODEN: NEJMAG
Source: ProQuest One Psychology
MEDLINE
Alma/SFX Local Collection
ProQuest Central

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Mutant Cohesin in Premature Ovarian Failure

Searching Remote Databases, Please Wait