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Quadrivalent Vaccine against Human Papillomavirus to Prevent Anogenital Diseases

The New England journal of medicine, 2007-05, Vol.356 (19), p.1928-1943 [Peer Reviewed Journal]

Copyright © 2007 Massachusetts Medical Society. All rights reserved. ;2007 INIST-CNRS ;Copyright 2007 Massachusetts Medical Society. ;ISSN: 0028-4793 ;EISSN: 1533-4406 ;DOI: 10.1056/NEJMoa061760 ;PMID: 17494926 ;CODEN: NEJMAG

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Title:
Quadrivalent Vaccine against Human Papillomavirus to Prevent Anogenital Diseases
Author: Garland, Suzanne M ; Hernandez-Avila, Mauricio ; Wheeler, Cosette M ; Perez, Gonzalo ; Harper, Diane M ; Leodolter, Sepp ; Tang, Grace W.K ; Ferris, Daron G ; Steben, Marc ; Bryan, Janine ; Taddeo, Frank J ; Railkar, Radha ; Esser, Mark T ; Sings, Heather L ; Nelson, Micki ; Boslego, John ; Sattler, Carlos ; Barr, Eliav ; Koutsky, Laura A
Subjects: Adenocarcinoma - prevention & control ; Adolescent ; Adult ; Alphapapillomavirus - genetics ; Alphapapillomavirus - isolation & purification ; Biological and medical sciences ; Carcinoma in Situ - epidemiology ; Carcinoma in Situ - prevention & control ; Cervical cancer ; Clinical outcomes ; Clinical trials ; Condylomata Acuminata - epidemiology ; Condylomata Acuminata - prevention & control ; Disease prevention ; DNA, Viral - blood ; Double-Blind Method ; Female ; Follow-Up Studies ; General aspects ; Genital diseases, Female ; Genital Neoplasms, Female - epidemiology ; Genital Neoplasms, Female - prevention & control ; Human papillomavirus ; Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18 ; Humans ; Medical sciences ; Papillomavirus Infections - prevention & control ; Papillomavirus Vaccines - adverse effects ; Prevention ; Prevention and actions ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Vaccines
Is Part Of: The New England journal of medicine, 2007-05, Vol.356 (19), p.1928-1943
Description: Human papillomaviruses are an important cause of genital warts and cervical cancer. In this large, randomized, placebo-controlled trial, a quadrivalent HPV vaccine given at day 1, month 2, and month 6 was found to significantly reduce the occurrence of cervical intraepithelial neoplasia and vulval or vaginal perianal lesions. No beneficial effect was observed on prevalent lesions. The benefit for prevention of incident lesions associated with HPV-16 and HPV-18 appears to increase with time. A quadrivalent HPV vaccine was found to significantly reduce the occurrence of cervical intraepithelial neoplasia and vulval or vaginal perianal lesions. Anogenital infection with the human papillomavirus (HPV) can cause warts, intraepithelial neoplasia, and invasive cancers. 1 – 6 The majority of HPV-associated diseases are caused by HPV types 6, 11, 16, and 18. HPV types 6 (HPV-6) and 11 (HPV-11) cause most anogenital warts, a portion of the cases of low-grade neoplasia, 5 , 7 – 10 and recurrent respiratory papillomatosis, a rare but potentially life-threatening disease. 11 – 13 HPV type 16 (HPV-16) is the most common cause of invasive cancers of the cervix and other anogenital cancers associated with HPV. 4 , 6 , 14 – 19 HPV type 18 (HPV-18), the second most common cause of cervical cancer, . . .
Publisher: Boston, MA: Massachusetts Medical Society
Language: English
Identifier: ISSN: 0028-4793
EISSN: 1533-4406
DOI: 10.1056/NEJMoa061760
PMID: 17494926
CODEN: NEJMAG
Source: ProQuest One Psychology
MEDLINE
Alma/SFX Local Collection
ProQuest Central

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Quadrivalent Vaccine against Human Papillomavirus to Prevent Anogenital Diseases

Copyright © 2007 Massachusetts Medical Society. All rights reserved. ;2007 INIST-CNRS ;Copyright 2007 Massachusetts Medical Society. ;ISSN: 0028-4793 ;EISSN: 1533-4406 ;DOI: 10.1056/NEJMoa061760 ;PMID: 17494926 ;CODEN: NEJMAG

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