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1,2,3,4,6‐Penta‐O‐galloyl‐β‐d‐glucose modulates perivascular inflammation and prevents vascular dysfunction in angiotensin II‐induced hypertension

British journal of pharmacology, 2019-06, Vol.176 (12), p.1951-1965 [Peer Reviewed Journal]

2019 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society. ;2019. This article is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;ISSN: 0007-1188 ;EISSN: 1476-5381 ;DOI: 10.1111/bph.14583 ;PMID: 30658013

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Title:
1,2,3,4,6‐Penta‐O‐galloyl‐β‐d‐glucose modulates perivascular inflammation and prevents vascular dysfunction in angiotensin II‐induced hypertension
Author: Mikolajczyk, Tomasz P. ; Nosalski, Ryszard ; Skiba, Dominik S. ; Koziol, Joanna ; Mazur, Magdalena ; Justo‐Junior, Amauri S. ; Kowalczyk, Paulina ; Kusmierczyk, Zofia ; Schramm‐Luc, Agata ; Luc, Kevin ; Maffia, Pasquale ; Graham, Delyth ; Kiss, Anna K. ; Naruszewicz, Marek ; Guzik, Tomasz J.
Subjects: Adipose tissue ; Angiotensin ; Angiotensin II ; Angiotensin II - administration & dosage ; Animals ; Aorta ; CCR5 protein ; CD25 antigen ; CD3 antigen ; CD4 antigen ; CD44 antigen ; CD8 antigen ; Glucose ; Humans ; Hydrolyzable Tannins - chemistry ; Hydrolyzable Tannins - isolation & purification ; Hydrolyzable Tannins - pharmacology ; Hypertension ; Hypertension - chemically induced ; Hypertension - drug therapy ; Inflammation ; Inflammation - drug therapy ; Inflammation - metabolism ; Injections, Subcutaneous ; Interferon ; Male ; Mice ; Mice, Inbred C57BL ; Monocyte chemoattractant protein ; Monocyte chemoattractant protein 1 ; Monocytes ; Oenothera - chemistry ; RANTES ; Research Paper ; Superoxide ; Themed Section: Research Paper ; Tumor Cells, Cultured ; Tumor necrosis factor ; Ventricular Dysfunction - drug therapy ; Ventricular Dysfunction - metabolism
Is Part Of: British journal of pharmacology, 2019-06, Vol.176 (12), p.1951-1965
Description: Background and Purpose Hypertension is a multifactorial disease, manifested by vascular dysfunction, increased superoxide production, and perivascular inflammation. In this study, we have hypothesized that 1,2,3,4,6‐penta‐O‐galloyl‐β‐d‐glucose (PGG) would inhibit vascular inflammation and protect from vascular dysfunction in an experimental model of hypertension. Experimental Approach PGG was administered to mice every 2 days at a dose of 10 mg·kg−1 i.p during 14 days of Ang II infusion. It was used at a final concentration of 20 μM for in vitro studies in cultured cells. Key Results Ang II administration increased leukocyte and T‐cell content in perivascular adipose tissue (pVAT), and administration of PGG significantly decreased total leukocyte and T‐cell infiltration in pVAT. This effect was observed in relation to all T‐cell subsets. PGG also decreased the content of T‐cells bearing CD25, CCR5, and CD44 receptors and the expression of both monocyte chemoattractant protein 1 (CCL2) in aorta and RANTES (CCL5) in pVAT. PGG administration decreased the content of TNF+ and IFN‐γ+ CD8 T‐cells and IL‐17A+ CD4+ and CD3+CD4−CD8− cells. Importantly, these effects of PGG were associated with improved vascular function and decreased ROS production in the aortas of Ang II‐infused animals independently of the BP increase. Mechanistically, PGG (20 μM) directly inhibited CD25 and CCR5 expression in cultured T‐cells. It also decreased the content of IFN‐γ+ CD8+ and CD3+CD4−CD8− cells and IL‐17A+ CD3+CD4−CD8− cells. Conclusion and Implication PGG may constitute an interesting immunomodulating strategy in the regulation of vascular dysfunction and hypertension. Linked Articles This article is part of a themed section on Immune Targets in Hypertension. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.12/issuetoc
Publisher: England: Blackwell Publishing Ltd
Language: English
Identifier: ISSN: 0007-1188
EISSN: 1476-5381
DOI: 10.1111/bph.14583
PMID: 30658013
Source: GFMER Free Medical Journals
MEDLINE
PubMed Central

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1,2,3,4,6‐Penta‐O‐galloyl‐β‐d‐glucose modulates perivascular inflammation and prevents vascular dysfunction in angiotensin II‐induced hypertension

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