skip to main content
Language:
Search Limited to: Search Limited to: Resource type Show Results with: Show Results with: Search type Index

Quercetin induces dual specificity phosphatase 5 via serum response factor

BMB reports, 2023-09, Vol.56 (9), p.508-513 [Peer Reviewed Journal]

Copyright © 2023 by the The Korean Society for Biochemistry and Molecular Biology 2023 ;ISSN: 1976-6696 ;EISSN: 1976-670X ;DOI: 10.5483/BMBRep.2023-0051 ;PMID: 37291053

Full text available

Citations Cited by
  • Title:
    Quercetin induces dual specificity phosphatase 5 via serum response factor
  • Author: Boonruang, Kanokkan ; Kim, Ilju ; Kwag, Chaeyoung ; Ryu, Junsun ; Baek, Seung Joon
  • Subjects: Colorectal cancer ; DUSP5 ; ERK ; Quercetin ; SRF
  • Is Part Of: BMB reports, 2023-09, Vol.56 (9), p.508-513
  • Description: The phytochemical quercetin has gained attention for its antiinflammatory and anti-tumorigenic properties in various types of cancer. Tumorigenesis involves the aberrant regulation of kinase/phosphatase, highlighting the importance of maintaining homeostasis. Dual Specificity Phosphatase (DUSP) plays a crucial role in controlling the phosphorylation of ERK. The current study aimed to clone the DUSP5 promoter, and investigate its transcriptional activity in the presence of quercetin. The results revealed that quercetin-induced DUSP5 expression is associated with the serum response factor (SRF) binding site located in the DUSP5 promoter. The deletion of this site abolished the luciferase activity induced by quercetin, indicating its vital role in quercetin-induced DUSP5 expression. SRF protein is a transcription factor that potentially contributes to quercetin- induced DUSP5 expression at the transcriptional level. Additionally, quercetin enhanced SRF binding activity without changing its expression. These findings provide evidence of how quercetin affects anti-cancer activity in colorectal tumorigenesis by inducing SRF transcription factor activity, thereby increasing DUSP5 expression at the transcriptional level. This study highlights the importance of investigating the molecular mechanisms underlying the anti-cancer properties of quercetin, and suggests its potential use in cancer therapy. [BMB Reports 2023; 56(9): 508-513]
  • Publisher: 생화학분자생물학회
  • Language: Korean;English
  • Identifier: ISSN: 1976-6696
    EISSN: 1976-670X
    DOI: 10.5483/BMBRep.2023-0051
    PMID: 37291053
  • Source: Freely Accessible Journals
    PMC (PubMed Central)
    ROAD: Directory of Open Access Scholarly Resources
Back to results list
INSPIRE LIBRARY - TON DUC THANG UNIVERSITY (84-028) 37 755 057 Feedback
19 Nguyen Huu Tho St. Dist.7, HCM thuvien@tdtu.edu.vn

Copyright © 2017 INSPIRE LIBRARY - TON DUC THANG UNIVERSITY

Searching Remote Databases, Please Wait