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Prostate Cancer Grading: A Decade After the 2005 Modified Gleason Grading System

Archives of pathology & laboratory medicine (1976), 2016-10, Vol.140 (10), p.1140-1152 [Peer Reviewed Journal]

COPYRIGHT 2016 College of American Pathologists ;COPYRIGHT 2016 College of American Pathologists ;Copyright College of American Pathologists Oct 2016 ;ISSN: 0003-9985 ;ISSN: 1543-2165 ;EISSN: 1543-2165 ;DOI: 10.5858/arpa.2015-0487-SA ;PMID: 26756649 ;CODEN: APLMAS

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  • Title:
    Prostate Cancer Grading: A Decade After the 2005 Modified Gleason Grading System
  • Author: Kryvenko, Oleksandr N ; Epstein, Jonathan I
  • Subjects: Humans ; Immunohistochemistry ; International Cooperation ; Male ; Neoplasm Grading - methods ; Neoplasm Grading - standards ; Neoplasm Grading - trends ; Pathologists ; Pathology, Clinical - methods ; Pathology, Clinical - standards ; Pathology, Clinical - trends ; Prostate - pathology ; Prostate cancer ; Prostatic Neoplasms - diagnosis ; Prostatic Neoplasms - pathology ; Reproducibility of Results ; Sensitivity and Specificity
  • Is Part Of: Archives of pathology & laboratory medicine (1976), 2016-10, Vol.140 (10), p.1140-1152
  • Description: Since 1966, when Donald Gleason, MD, first proposed grading prostate cancer based on its histologic architecture, there have been numerous changes in clinical and pathologic practices relating to prostate cancer. Patterns 1 and 2, comprising more than 30% of cases in the original publications by Gleason, are no longer reported on biopsy and are rarely diagnosed on radical prostatectomy. Many of these cases may even have been mimickers of prostate cancer that were described later with the use of contemporary immunohistochemistry. The original Gleason system predated many newly described variants of prostate cancer and our current concept of intraductal carcinoma. Gleason also did not describe how to report prostate cancer on biopsy with multiple cores of cancer or on radical prostatectomy with separate tumor nodules. To address these issues, the International Society of Urological Pathology first made revisions to the grading system in 2005, and subsequently in 2014. Additionally, a new grading system composed of Grade Groups 1 to 5 that was first developed in 2013 at the Johns Hopkins Hospital and subsequently validated in a large multi-institutional and multimodal study was presented at the 2014 International Society of Urological Pathology meeting and accepted both by participating pathologists as well as urologists, oncologists, and radiation therapists. In the present study, we describe updates to the grading of prostate cancer along with the new grading system.
  • Publisher: United States: College of American Pathologists
  • Language: English
  • Identifier: ISSN: 0003-9985
    ISSN: 1543-2165
    EISSN: 1543-2165
    DOI: 10.5858/arpa.2015-0487-SA
    PMID: 26756649
    CODEN: APLMAS
  • Source: MEDLINE
    Alma/SFX Local Collection
    ProQuest Central
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