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Lead in Health and Disease

Indian journal of clinical biochemistry, 2022-05, Vol.29 (S1), p.S14 [Peer Reviewed Journal]

COPYRIGHT 2022 Springer ;ISSN: 0970-1915 ;EISSN: 0974-0422

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  • Title:
    Lead in Health and Disease
  • Author: Sharma, Praveen
  • Subjects: Developing countries
  • Is Part Of: Indian journal of clinical biochemistry, 2022-05, Vol.29 (S1), p.S14
  • Description: Widespread use of Lead has caused extensive environmental contamination and health problems in many parts of the world. It is a cumulative toxicant that affects multiple body systems, including the neurologic, hematologic, gastrointestinal, cardiovascular, reproductive and renal systems. Lead exposure is estimated to account for 0.6% of the global burden of disease, with the highest burden in developing regions. Childhood lead exposure is estimated to contribute to about 600,000 new cases of children with intellectual disabilities every year. The developing nervous system of children is most susceptible to deleterious effects of lead. Subtle effects on intelligence quotient (IQ) are expected from blood lead levels at least as low as 5 [micro]g/dl and the effects gradually increase with increasing levels of lead in blood. Prenatal exposure of Lead also has been documented with developmental delays. In adults low lead exposure has been correlated with rise in systolic blood pressure as well as has been found to effect sperm count and sperm motility. Relationship of lead with anaemia is well documented in adults as well as children. Recent reductions in the use of lead in petrol, plumbing and solder have resulted in substantial reductions in blood lead levels. However, significant sources of exposure still remain, particularly in developing countries. Effect of lead on different organ systems as well as potential research areas will be discussed.
  • Publisher: Springer
  • Language: English
  • Identifier: ISSN: 0970-1915
    EISSN: 0974-0422
  • Source: Geneva Foundation Free Medical Journals at publisher websites
    PubMed Central
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