Language:

Cardiovascular disease and COVID-19: a consensus paper from the ESC Working Group on Coronary Pathophysiology & Microcirculation, ESC Working Group on Thrombosis and the Association for Acute CardioVascular Care (ACVC), in collaboration with the European Heart Rhythm Association (EHRA)

Cardiovascular Research, 2021-12, Vol.117 (14), p.2705-2729 [Peer Reviewed Journal]

Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2021. For permissions, please email: journals.permissions@oup.com. 2021 ;Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2021. For permissions, please email: journals.permissions@oup.com. ;2021. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the associated terms available at https://academic.oup.com/journals/pages/coronavirus . ;Distributed under a Creative Commons Attribution 4.0 International License ;ISSN: 0008-6363 ;EISSN: 1755-3245 ;DOI: 10.1093/cvr/cvab298 ;PMID: 34528075

Digital Resources/Online E-Resources

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Cardiovascular disease and COVID-19: a consensus paper from the ESC Working Group on Coronary Pathophysiology & Microcirculation, ESC Working Group on Thrombosis and the Association for Acute CardioVascular Care (ACVC), in collaboration with the European Heart Rhythm Association (EHRA)
Author: Cenko, Edina ; Badimon, Lina ; Bugiardini, Raffaele ; Claeys, Marc J ; De Luca, Giuseppe ; de Wit, Cor ; Derumeaux, Geneviève ; Dorobantu, Maria ; Duncker, Dirk J ; Eringa, Etto C ; Gorog, Diana A ; Hassager, Christian ; Heinzel, Frank R ; Huber, Kurt ; Manfrini, Olivia ; Milicic, Davor ; Oikonomou, Evangelos ; Padro, Teresa ; Trifunovic-Zamaklar, Danijela ; Vasiljevic-Pokrajcic, Zorana ; Vavlukis, Marija ; Vilahur, Gemma ; Tousoulis, Dimitris
Subjects: Angiotensin-Converting Enzyme 2 - metabolism ; Cardiometabolic Risk Factors ; Cardiovascular Diseases - enzymology ; Cardiovascular Diseases - physiopathology ; Cardiovascular Diseases - virology ; Clinical Trials as Topic ; COVID-19 - complications ; COVID-19 - enzymology ; COVID-19 - etiology ; COVID-19 - physiopathology ; COVID-19 - therapy ; Humans ; Inflammation - complications ; Inflammation - virology ; Life Sciences ; Microcirculation ; Post-Acute COVID-19 Syndrome ; Review ; Sex Characteristics
Is Part Of: Cardiovascular Research, 2021-12, Vol.117 (14), p.2705-2729
Description: Abstract The cardiovascular system is significantly affected in coronavirus disease-19 (COVID-19). Microvascular injury, endothelial dysfunction, and thrombosis resulting from viral infection or indirectly related to the intense systemic inflammatory and immune responses are characteristic features of severe COVID-19. Pre-existing cardiovascular disease and viral load are linked to myocardial injury and worse outcomes. The vascular response to cytokine production and the interaction between severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and angiotensin-converting enzyme 2 receptor may lead to a significant reduction in cardiac contractility and subsequent myocardial dysfunction. In addition, a considerable proportion of patients who have been infected with SARS-CoV-2 do not fully recover and continue to experience a large number of symptoms and post-acute complications in the absence of a detectable viral infection. This conditions often referred to as ‘post-acute COVID-19’ may have multiple causes. Viral reservoirs or lingering fragments of viral RNA or proteins contribute to the condition. Systemic inflammatory response to COVID-19 has the potential to increase myocardial fibrosis which in turn may impair cardiac remodelling. Here, we summarize the current knowledge of cardiovascular injury and post-acute sequelae of COVID-19. As the pandemic continues and new variants emerge, we can advance our knowledge of the underlying mechanisms only by integrating our understanding of the pathophysiology with the corresponding clinical findings. Identification of new biomarkers of cardiovascular complications, and development of effective treatments for COVID-19 infection are of crucial importance. Graphical Abstract
Publisher: England: Oxford University Press
Language: English
Identifier: ISSN: 0008-6363
EISSN: 1755-3245
DOI: 10.1093/cvr/cvab298
PMID: 34528075
Source: Coronavirus Research Database

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Cardiovascular disease and COVID-19: a consensus paper from the ESC Working Group on Coronary Pathophysiology & Microcirculation, ESC Working Group on Thrombosis and the Association for Acute CardioVascular Care (ACVC), in collaboration with the European Heart Rhythm Association (EHRA)

Searching Remote Databases, Please Wait