Language:

Cardiovascular Manifestations of COVID-19 Infection

Cells (Basel, Switzerland), 2020-11, Vol.9 (11), p.2508 [Peer Reviewed Journal]

COPYRIGHT 2020 MDPI AG ;2020. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2020 by the authors. 2020 ;ISSN: 2073-4409 ;EISSN: 2073-4409 ;DOI: 10.3390/cells9112508 ;PMID: 33228225

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Cardiovascular Manifestations of COVID-19 Infection
Author: Magadum, Ajit ; Kishore, Raj
Subjects: ACE2 ; Angiotensin ; Angiotensin-converting enzyme 2 ; Angiotensin-Converting Enzyme 2 - metabolism ; Animals ; Blood Platelets - metabolism ; Cardiomyopathy ; cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - metabolism ; Cardiovascular system ; Comorbidity ; Congestive heart failure ; Coronaviruses ; COVID-19 ; COVID-19 - epidemiology ; COVID-19 - virology ; Cytokine storm ; cytokine storm and inflammation ; Cytokines - metabolism ; Diabetes mellitus ; Disease Models, Animal ; Endothelial Cells - pathology ; Endothelial Cells - virology ; Health aspects ; Humans ; Hypoxia ; Immune response ; Interferon ; Morbidity ; Mortality ; myocardial injury ; Myocarditis ; Myocardium ; Pandemics ; Peptidyl-dipeptidase A ; Reactive Oxygen Species - metabolism ; Review ; Risk Factors ; SARS-CoV-2 ; SARS-CoV-2 - metabolism ; Severe acute respiratory syndrome coronavirus 2 ; Viral infections ; Virus Internalization
Is Part Of: Cells (Basel, Switzerland), 2020-11, Vol.9 (11), p.2508
Description: SARS-CoV-2 induced the novel coronavirus disease (COVID-19) outbreak, the most significant medical challenge in the last century. COVID-19 is associated with notable increases in morbidity and death worldwide. Preexisting conditions, like cardiovascular disease (CVD), diabetes, hypertension, and obesity, are correlated with higher severity and a significant increase in the fatality rate of COVID-19. COVID-19 induces multiple cardiovascular complexities, such as cardiac arrest, myocarditis, acute myocardial injury, stress-induced cardiomyopathy, cardiogenic shock, arrhythmias and, subsequently, heart failure (HF). The precise mechanisms of how SARS-CoV-2 may cause myocardial complications are not clearly understood. The proposed mechanisms of myocardial injury based on current knowledge are the direct viral entry of the virus and damage to the myocardium, systemic inflammation, hypoxia, cytokine storm, interferon-mediated immune response, and plaque destabilization. The virus enters the cell through the angiotensin-converting enzyme-2 (ACE2) receptor and plays a central function in the virus's pathogenesis. A systematic understanding of cardiovascular effects of SARS-CoV2 is needed to develop novel therapeutic tools to target the virus-induced cardiac damage as a potential strategy to minimize permanent damage to the cardiovascular system and reduce the morbidity. In this review, we discuss our current understanding of COVID-19 mediated damage to the cardiovascular system.
Publisher: Switzerland: MDPI AG
Language: English
Identifier: ISSN: 2073-4409
EISSN: 2073-4409
DOI: 10.3390/cells9112508
PMID: 33228225
Source: MEDLINE
PubMed Central
Coronavirus Research Database
ROAD: Directory of Open Access Scholarly Resources
ProQuest Central
DOAJ Directory of Open Access Journals

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Cardiovascular Manifestations of COVID-19 Infection

Searching Remote Databases, Please Wait