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Antidepressant use and risk of intubation or death in hospitalized patients with COVID-19: A retrospective cohort study of clinical effectiveness

Frontiers in psychiatry, 2022-09, Vol.13, p.951065-951065 [Peer Reviewed Journal]

Copyright © 2022 Brennan, Schnabel, Pope and Hudson. 2022 Brennan, Schnabel, Pope and Hudson ;ISSN: 1664-0640 ;EISSN: 1664-0640 ;DOI: 10.3389/fpsyt.2022.951065

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  • Title:
    Antidepressant use and risk of intubation or death in hospitalized patients with COVID-19: A retrospective cohort study of clinical effectiveness
  • Author: Brennan, Brian P. ; Schnabel, Jiana ; Pope, Harrison G. ; Hudson, James I.
  • Subjects: antidepressants ; clinical effectiveness ; COVID-19 ; Psychiatry ; retrospective cohort study ; selective serotonin reuptake inhibitors ; serotonin-norepinephrine reuptake inhibitors
  • Is Part Of: Frontiers in psychiatry, 2022-09, Vol.13, p.951065-951065
  • Description: Initial controlled trials of the serotonergic antidepressant fluvoxamine showed promise for treatment of mild to moderate COVID-19 in outpatients, although more recent outpatient data have been less encouraging. Turning to studies of hospitalized patients, a retrospective cohort study by Hoertel and associates in 2021 found a markedly reduced risk of intubation or death among patients hospitalized with COVID-19 who were receiving serotonergic antidepressants at the time of admission vs. those not receiving antidepressants. In an attempt to replicate these latter findings, we performed a similarly designed study of 500 individuals hospitalized with COVID-19 in a large academic hospital system who were taking a serotonergic antidepressant at the time of admission compared with two groups ( N = 573 and N = 593) not receiving an antidepressant. In analyses controlling for demographic and clinical variables, we found no significant difference in effect between the antidepressant group and either of the two comparison groups [hazard ratios (95% CI) for intubation or death 1.1 (0.83–1.5) and 1.1 (0.86–1.5); and for death alone 1.3 (0.93–1.8) and 1.1 (0.85–1.7)]. Examining the results of our study, along with those of Hoertel et al. and three additional retrospective cohort studies in inpatients published in the interim, the data permit only very limited conclusions, with the findings on the effect of serotonergic antidepressants ranging from a strongly protective effect to no effect. Although there are numerous threats to validity that might account for this wide range of findings, we could not identify any principal factor or set of factors that could clearly explain the differences.
  • Publisher: Frontiers Media S.A
  • Language: English
  • Identifier: ISSN: 1664-0640
    EISSN: 1664-0640
    DOI: 10.3389/fpsyt.2022.951065
  • Source: Geneva Foundation Free Medical Journals at publisher websites
    PubMed Central
    ROAD: Directory of Open Access Scholarly Resources
    DOAJ Directory of Open Access Journals
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