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Mitochondria in Sepsis-Induced AKI

Journal of the American Society of Nephrology, 2019-07, Vol.30 (7), p.1151-1161 [Peer Reviewed Journal]

Copyright © 2019 by the American Society of Nephrology. ;Copyright © 2019 by the American Society of Nephrology 2019 ;ISSN: 1046-6673 ;EISSN: 1533-3450 ;DOI: 10.1681/asn.2018111126 ;PMID: 31076465

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Title:
Mitochondria in Sepsis-Induced AKI
Author: Sun, Jian ; Zhang, Jingxiao ; Tian, Jiakun ; Virzì, Grazia Maria ; Digvijay, Kumar ; Cueto, Laura ; Yin, Yongjie ; Rosner, Mitchell H ; Ronco, Claudio
Subjects: Acute Kidney Injury - drug therapy ; Acute Kidney Injury - etiology ; Antioxidants - therapeutic use ; Energy Metabolism ; Humans ; Mitochondria - drug effects ; Mitochondria - physiology ; Mitophagy - drug effects ; Reactive Oxygen Species - metabolism ; Sepsis - complications ; Superoxides - metabolism ; Up Front Matters
Is Part Of: Journal of the American Society of Nephrology, 2019-07, Vol.30 (7), p.1151-1161
Description: AKI is a common clinical condition associated with the risk of developing CKD and ESKD. Sepsis is the leading cause of AKI in the intensive care unit (ICU) and accounts for nearly half of all AKI events. Patients with AKI who require dialysis have an unacceptably high mortality rate of 60%-80%. During sepsis, endothelial activation, increased microvascular permeability, changes in regional blood flow distribution with resulting areas of hypoperfusion, and hypoxemia can lead to AKI. No effective drugs to prevent or treat human sepsis-induced AKI are currently available. Recent research has identified dysfunction in energy metabolism as a critical contributor to the pathogenesis of AKI. Mitochondria, the center of energy metabolism, are increasingly recognized to be involved in the pathophysiology of sepsis-induced AKI and mitochondria could serve as a potential therapeutic target. In this review, we summarize the potential role of mitochondria in sepsis-induced AKI and identify future therapeutic approaches that target mitochondrial function in an effort to treat sepsis-induced AKI.
Publisher: United States: American Society of Nephrology
Language: English
Identifier: ISSN: 1046-6673
EISSN: 1533-3450
DOI: 10.1681/asn.2018111126
PMID: 31076465
Source: Geneva Foundation Free Medical Journals at publisher websites
MEDLINE
Alma/SFX Local Collection
PubMed Central（OA）

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Mitochondria in Sepsis-Induced AKI

Copyright © 2019 by the American Society of Nephrology. ;Copyright © 2019 by the American Society of Nephrology 2019 ;ISSN: 1046-6673 ;EISSN: 1533-3450 ;DOI: 10.1681/asn.2018111126 ;PMID: 31076465

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