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Genetic Vulnerability as a Distal Risk Factor for Suicidal Behaviour: Historical Perspective And Current Knowledge / Genetska Ranljivost Kot Oddaljen Dejavnik Tveganja Za Samomorilno Vedenje: Zgodovinski Vidik In Znanje Danes

Zdravstveno varstvo, 2015-09, Vol.54 (3), p.238-251 [Peer Reviewed Journal]

Copyright De Gruyter Open Sp. z o.o. 2015 ;ISSN: 1854-2476 ;ISSN: 0351-0026 ;EISSN: 1854-2476 ;DOI: 10.1515/sjph-2015-0026

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  • Title:
    Genetic Vulnerability as a Distal Risk Factor for Suicidal Behaviour: Historical Perspective And Current Knowledge / Genetska Ranljivost Kot Oddaljen Dejavnik Tveganja Za Samomorilno Vedenje: Zgodovinski Vidik In Znanje Danes
  • Author: Andriessen, Karl ; Videtic-Paska, Alja
  • Subjects: Behavioral psychology ; družine ; ethical considerations ; etična vprašanja ; families ; Genetics ; genetika ; History ; Knowledge ; offsprings ; potomci ; pregledni članki ; preiskovanci ; probands ; ranljivost ; review ; samomor ; samomorilno vedenje ; suicidal behaviour ; suicide ; Suicides & suicide attempts ; vulnerability
  • Is Part Of: Zdravstveno varstvo, 2015-09, Vol.54 (3), p.238-251
  • Description: Introduction. Suicide is a multidimensional problem. Observations of family history of suicide suggest the existence of a genetic vulnerability to suicidal behaviour. Aim. Starting with a historical perspective, the article reviews current knowledge of a genetic vulnerability to suicidal behaviour, distinct from the genetic vulnerability to psychiatric disorders, focused on clinical and population-based studies, and findings from recent molecular genetics association studies. Method. The review includes peer-reviewed research articles and review papers from the professional literature in English language, retrieved from PubMed/Medline and PsycINFO. Results. The research literature confirms a existence of a genetic vulnerability to suicidal behaviour. Even though the results of individual studies are difficult to compare, genetic influences could explain up to half of the variance of the occurrence of suicide. Conclusion. Genetic vulnerability could be a distal risk factor for suicide, which helps us to understand the occurrence of suicide among vulnerable people. Ethical implications of such vulnerability are highlighted. Uvod. Samomor je večrazsežnostni problem. S študijami družinskih anamnez samomorilnega vedenja je bilo ugotovljeno, da bi genetska komponenta lahko vplivala na občutljivost za samomorilno vedenje. Namen. Članek skozi zgodovinski vidik proučuje današnje poznavanje genetske ranljivosti za samomorilno vedenje, ki se razlikuje od genetske ranljivosti za psihiatrične motnje v kliničnih in populacijskih študijah ter prikazuje ugotovitve zadnjih študij molekularno genetskih raziskav. Metoda. Strokovni pregled vključuje raziskovalne članke in poročila iz strokovne literature v angleškem jeziku, pridobljene iz PubMed/Medine in PsycINFO. Rezultati. Pregled obstoječe strokovne literature kaže na prisotnost genetske komponente kot dejavnika tveganja za samomorilno vedenje. Čeprav je rezultate posameznih študij težko primerjati, pa lahko genetski vplivi pojasnijo tudi do polovico različnih pojavov samomorilnega vedenja. Zaključek. Genetska ranljivost bi lahko bila distalni dejavnik tveganja za samomor, kar nam pomaga razumeti pojav samomora med osebami s tveganjem za samomorilno vedenje. S tega pogleda so zajeta tudi etična vprašanja.
  • Publisher: Ljubljana: De Gruyter Open
  • Language: English;Slovenian
  • Identifier: ISSN: 1854-2476
    ISSN: 0351-0026
    EISSN: 1854-2476
    DOI: 10.1515/sjph-2015-0026
  • Source: PubMed Central
    De Gruyter Open Access Journals
    ProQuest Central
    DOAJ Directory of Open Access Journals
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