skip to main content
Language:
Search Limited to: Search Limited to: Resource type Show Results with: Show Results with: Search type Index

Highly specific blockade of CCR5 inhibits leukocyte trafficking and reduces mucosal inflammation in murine colitis

Scientific reports, 2016-08, Vol.6 (1), p.30802-30802, Article 30802 [Peer Reviewed Journal]

Copyright Nature Publishing Group Aug 2016 ;Copyright © 2016, The Author(s) 2016 The Author(s) ;ISSN: 2045-2322 ;EISSN: 2045-2322 ;DOI: 10.1038/srep30802 ;PMID: 27492684

Full text available

Citations Cited by
  • Title:
    Highly specific blockade of CCR5 inhibits leukocyte trafficking and reduces mucosal inflammation in murine colitis
  • Author: Mencarelli, Andrea ; Cipriani, Sabrina ; Francisci, Daniela ; Santucci, Luca ; Baldelli, Franco ; Distrutti, Eleonora ; Fiorucci, Stefano
  • Subjects: Adoptive transfer ; Animal models ; CCR5 protein ; CD11b antigen ; CD4 antigen ; Cell activation ; Colitis ; Colon ; Inflammation ; Inflammatory bowel disease ; Inflammatory bowel diseases ; Intestine ; Leukocyte migration ; Lymphocytes T ; Mucosa ; RAG1 protein ; RANTES ; Recruitment ; Rodents ; Spleen
  • Is Part Of: Scientific reports, 2016-08, Vol.6 (1), p.30802-30802, Article 30802
  • Description: Targeted disruption of leukocyte trafficking to the gut represents a promising approach for the treatment of inflammatory bowel diseases (IBDs). CCR5, the shared receptor for MIP1α and β and RANTES, is expressed by multiple leukocytes. Here, we aimed to determine the role of CCR5 in mediating leukocyte trafficking in models of colitis, and evaluate the therapeutic potential of maraviroc, an orally active CCR5 antagonist used in the treatment of CCR5-tropic HIV. Acute and chronic colitis were induced by administration of DSS or TNBS to wild-type and CCR5(-/-) mice or adoptive transfer of splenic naïve CD4(+) T-cells from wild type or CCR5(-/-) mice into RAG-1(-/-). CCR5 gene ablation reduced the mucosal recruitment and activation of CCR5-bearing CD4(+) and CD11b(+) leukocytes, resulting in profound attenuation of signs and symptoms of inflammation in the TNBS and transfer models of colitis. In the DSS/TNBS colitis and in the transfer model, maraviroc attenuated development of intestinal inflammation by selectively reducing the recruitment of CCR5 bearing leukocytes. In summary, CCR5 regulates recruitment of blood leukocytes into the colon indicating that targeting CCR5 may offer therapeutic options in IBDs.
  • Publisher: England: Nature Publishing Group
  • Language: English
  • Identifier: ISSN: 2045-2322
    EISSN: 2045-2322
    DOI: 10.1038/srep30802
    PMID: 27492684
  • Source: PubMed Central
    ProQuest Central
    DOAJ Directory of Open Access Journals
Back to results list
INSPIRE LIBRARY - TON DUC THANG UNIVERSITY (84-028) 37 755 057 Feedback
19 Nguyen Huu Tho St. Dist.7, HCM thuvien@tdtu.edu.vn

Copyright © 2017 INSPIRE LIBRARY - TON DUC THANG UNIVERSITY

Searching Remote Databases, Please Wait