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Evaluation of the association between persistent organic pollutants (POPs) and diabetes in epidemiological studies: a national toxicology program workshop review

Environmental health perspectives, 2013-07, Vol.121 (7), p.774-783 [Peer Reviewed Journal]

COPYRIGHT 2013 National Institute of Environmental Health Sciences ;COPYRIGHT 2013 National Institute of Environmental Health Sciences ;Copyright National Institute of Environmental Health Sciences Jul 2013 ;2013 ;ISSN: 0091-6765 ;ISSN: 1552-9924 ;EISSN: 1552-9924 ;DOI: 10.1289/ehp.1205502 ;PMID: 23651634

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Title:
Evaluation of the association between persistent organic pollutants (POPs) and diabetes in epidemiological studies: a national toxicology program workshop review
Author: Taylor, Kyla W ; Novak, Raymond F ; Anderson, Henry A ; Birnbaum, Linda S ; Blystone, Chad ; Devito, Michael ; Jacobs, David ; Köhrle, Josef ; Lee, Duk-Hee ; Rylander, Lars ; Rignell-Hydbom, Anna ; Tornero-Velez, Rogelio ; Turyk, Mary E ; Boyles, Abee L ; Thayer, Kristina A ; Lind, Lars
Subjects: Animals ; Arbetsmedicin och miljömedicin ; chemically induced ; Development and progression ; Diabetes ; Diabetes Mellitus, Type 2 - chemically induced ; Diabetes Mellitus, Type 2 - epidemiology ; Diagnosis ; environment ; Environmental Exposure ; Environmental Health and Occupational Health ; Environmental Pollutants - analysis ; Environmental Pollutants - toxicity ; Epidemiology ; glucose ; Health aspects ; Health risk assessment ; Health Sciences ; hormone ; Humans ; Hydrocarbons, Chlorinated - analysis ; Hydrocarbons, Chlorinated - toxicity ; Hälsovetenskap ; insulin ; Medical and Health Sciences ; Medicin och hälsovetenskap ; metabolic syndrome ; Mice ; Obesity ; Obesity - chemically induced ; Obesity - epidemiology ; persistent organic ; Persistent organic pollutants ; Pesticides ; pollutants ; pollution ; Rats ; Review ; Risk factors ; Studies ; toxicology
Is Part Of: Environmental health perspectives, 2013-07, Vol.121 (7), p.774-783
Description: Diabetes is a major threat to public health in the United States and worldwide. Understanding the role of environmental chemicals in the development or progression of diabetes is an emerging issue in environmental health. We assessed the epidemiologic literature for evidence of associations between persistent organic pollutants (POPs) and type 2 diabetes. Using a PubMed search and reference lists from relevant studies or review articles, we identified 72 epidemiological studies that investigated associations of persistent organic pollutants (POPs) with diabetes. We evaluated these studies for consistency, strengths and weaknesses of study design (including power and statistical methods), clinical diagnosis, exposure assessment, study population characteristics, and identification of data gaps and areas for future research. Heterogeneity of the studies precluded conducting a meta-analysis, but the overall evidence is sufficient for a positive association of some organochlorine POPs with type 2 diabetes. Collectively, these data are not sufficient to establish causality. Initial data mining revealed that the strongest positive correlation of diabetes with POPs occurred with organochlorine compounds, such as trans-nonachlor, dichlorodiphenyldichloroethylene (DDE), polychlorinated biphenyls (PCBs), and dioxins and dioxin-like chemicals. There is less indication of an association between other nonorganochlorine POPs, such as perfluoroalkyl acids and brominated compounds, and type 2 diabetes. Experimental data are needed to confirm the causality of these POPs, which will shed new light on the pathogenesis of diabetes. This new information should be considered by governmental bodies involved in the regulation of environmental contaminants.
Publisher: United States: National Institute of Environmental Health Sciences
Language: English
Identifier: ISSN: 0091-6765
ISSN: 1552-9924
EISSN: 1552-9924
DOI: 10.1289/ehp.1205502
PMID: 23651634
Source: Open Access: PubMed Central
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AUTh Library subscriptions: ProQuest Central
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Evaluation of the association between persistent organic pollutants (POPs) and diabetes in epidemiological studies: a national toxicology program workshop review

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