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Association of phthalate exposure with thyroid function during pregnancy

Environment international, 2021-12, Vol.157, p.106795-106795, Article 106795 [Peer Reviewed Journal]

2021 The Authors ;Distributed under a Creative Commons Attribution 4.0 International License ;ISSN: 0160-4120 ;ISSN: 1873-6750 ;EISSN: 1873-6750 ;DOI: 10.1016/j.envint.2021.106795

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Title:
Association of phthalate exposure with thyroid function during pregnancy
Author: Derakhshan, Arash ; Shu, Huan ; Broeren, Maarten A.C. ; Lindh, Christian H. ; Peeters, Robin P. ; Kortenkamp, Andreas ; Demeneix, Barbara ; Bornehag, Carl-Gustaf ; Korevaar, Tim I.M.
Subjects: Arbetsmedicin och miljömedicin ; Biomolecules ; Early pregnancy ; Endocrine disrupters ; Endocrine disrupting chemicals ; Environmental Health and Occupational Health ; Esters ; Folkhälsovetenskap ; Health Sciences ; Hälsovetenskap ; Life Sciences ; Medical and Health Sciences ; Medicin och hälsovetenskap ; Metabolite concentrations ; Metabolites ; Molar concentration ; Molar ratio ; Obstetrics ; Phthalate exposures ; Phthalate metabolites ; Phthalates ; Pregnancy ; Public Health Science ; Thyroid ; Thyroid function ; Thyroid stimulating hormones ; Thyroid systems
Is Part Of: Environment international, 2021-12, Vol.157, p.106795-106795, Article 106795
Description: •Exposure to phthalates disrupt the maternal thyroid system.•Metabolites of DEHP can disrupt the maternal hypothalamic-pituitary-thyroid axis.•Several phthalates can increase the maternal T4 metabolism.•Phthalate substitutes such as DINCH are also capable of thyroid system disruption. The extent of thyroid disruptive effects of phthalates during pregnancy remains unclear. To investigate the association of maternal urinary phthalates with markers of the thyroid system during early pregnancy. Urinary concentrations of phthalate metabolites and serum concentrations of thyroid stimulating hormone (TSH), free and total thyroxine (FT4 and TT4) and free and total triiodothyronine (FT3 and TT3) were measured in pregnant women in early pregnancy in the Swedish Environmental Longitudinal, Mother and child, Asthma and allergy study (2007-ongoing), a population-based prospective cohort. In the 1,996 included women, higher di-ethyl-hexyl phthalate (DEHP) metabolites were associated with a lower FT4 (β [SE] for the molar sum: −0.13 [0.06], P = 0.03) and a higher TSH/FT4 ratio (0.003 [0.001], P = 0.03). Higher concentrations of di-iso-nonyl phthalate (DINP) metabolites were associated with a lower TT4 (β [SE] for the molar sum: 0.93 [0.44], P = 0.03) as well as with lower TT4/FT4 and TT4/TT3 ratios. Higher metabolites of both dibutyl and butyl-benzyl phthalate (DBP and BBzP) were associated with lower T4/T3 ratio (free and total) and higher FT4/TT4 and FT3/TT3 ratios. A higher diisononyl cyclohexane dicarboxylate (DINCH) metabolite concentration was associated with a higher TT3. These results translate results from experimental studies suggesting that exposure to phthalates may interfere with the thyroid system during pregnancy. This is also true for compounds that have been introduced to replace known disruptive phthalates. Further experimental studies should take into account the human evidence to better investigate the potential underlying mechanisms of thyroid disruption by phthalates.
Publisher: Elsevier Ltd
Language: English
Identifier: ISSN: 0160-4120
ISSN: 1873-6750
EISSN: 1873-6750
DOI: 10.1016/j.envint.2021.106795
Source: SWEPUB Freely available online
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Association of phthalate exposure with thyroid function during pregnancy

2021 The Authors ;Distributed under a Creative Commons Attribution 4.0 International License ;ISSN: 0160-4120 ;ISSN: 1873-6750 ;EISSN: 1873-6750 ;DOI: 10.1016/j.envint.2021.106795

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