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Determinants of serum half-lives for linear and branched perfluoroalkyl substances after long-term high exposure—A study in Ronneby, Sweden

Environment international, 2022-05, Vol.163, p.107198-107198, Article 107198 [Peer Reviewed Journal]

2022 ;Crown Copyright © 2022. Published by Elsevier Ltd. All rights reserved. ;ISSN: 0160-4120 ;ISSN: 1873-6750 ;EISSN: 1873-6750 ;DOI: 10.1016/j.envint.2022.107198 ;PMID: 35447437

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  • Title:
    Determinants of serum half-lives for linear and branched perfluoroalkyl substances after long-term high exposure—A study in Ronneby, Sweden
  • Author: Li, Ying ; Andersson, Axel ; Xu, Yiyi ; Pineda, Daniela ; Nilsson, Carina A ; Lindh, Christian H. ; Jakobsson, Kristina ; Fletcher, Tony
  • Subjects: acids ; Arbetsmedicin och miljömedicin ; Branched PFOS-isomers ; clearance ; Determinants ; elimination ; Environmental Health and Occupational Health ; Environmental Sciences & Ecology ; fecal calprotectin ; fish ; Health Sciences ; humans ; Hälsovetenskap ; Medical and Health Sciences ; Medicin och hälsovetenskap ; Miljömedicin och yrkesmedicin ; perfluorooctanoate ; permeability ; PFAS ; pfoa ; Serum half-life ; urine
  • Is Part Of: Environment international, 2022-05, Vol.163, p.107198-107198, Article 107198
  • Description: [Display omitted] •This study provides refined estimates of the half-life of eight PFAS, especially including the branched PFOS-isomers.•The determinants leading to shorter half-life were young age; better kidney function; female gender in fertile age; and possibly gut inflammation and lower gut permeability.•The result also suggested a time-dependent PFAS elimination process, with more rapid elimination in the first year after the end of exposure, than later. Per- and polyfluoroalkyl substances (PFAS) are persistent substances with surfactant and repellent properties. Municipal drinking water contaminated with PFAS had been distributed for decades to one third of households in Ronneby, Sweden. The source was firefighting foam used in a nearby airfield since the mid-1980s. Clean water was provided from December 16, 2013. The purpose was to estimate serum half-lives and their determinants in the study population for different PFAS. Up to ten blood samples were collected between 2014 and 2018 from 114 participants (age 4–84 years at entry, 53% female). 19 PFAS were analysed. Linear mixed models were used to estimate the half-lives. Eight PFAS were increased in Ronneby: perfluorooctanoic acid (PFOA), perfluoropentane sulfonate (PFPeS), perfluorohexane sulfonate (PFHxS), perfluoroheptane sulfonate (PFHpS), linear perfluorooctane sulfonate (L-PFOS) and three branched perfluorooctane sulfonates (1 m-PFOS, 3/4/5m-PFOS and 2/6m-PFOS). The mean estimated half-lives (in years) were 0.94 (95 %CI 0.86–1.02) for PFPeS, 2.47 (2.27–2.7) for PFOA, 2.67 (2.51–2.85) for 2/6m-PFOS, 2.73 (2.55–2.92) for L-PFOS, 3.43 (3.19–3.71) for 3/4/5m-PFOS, 4.52 (4.14–4.99) for PFHxS, 4.55 (4.14–5.06) for PFHpS, and 5.01 (4.56–5.55) for 1 m-PFOS. The most important determinants of a shorter half-life were young age, and better kidney function measured by estimated glomerular filtration rate and ratio of paired urine and serum PFAS levels, followed by female sex during their fertile period aged 15–50. Markers of gut inflammation and reduced permeability i.e. zonulin and calprotectin were also possibly associated with shorter half-life. The results also suggested a time-dependent PFAS elimination process, with more rapid elimination in the first year after the end of exposure. The half-life estimates are in line with past estimates for some PFAS such as PFOA, and the novel results for different PFOS isomers. These results provide observational support for elimination routes – renal, fecal and maternal.
  • Publisher: Netherlands: Elsevier Ltd
  • Language: English
  • Identifier: ISSN: 0160-4120
    ISSN: 1873-6750
    EISSN: 1873-6750
    DOI: 10.1016/j.envint.2022.107198
    PMID: 35447437
  • Source: SWEPUB Freely available online
    DOAJ Directory of Open Access Journals
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