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Randomised trials of secondary prevention programmes in coronary heart disease: systematic review

BMJ, 2001-10, Vol.323 (7319), p.957-962 [Peer Reviewed Journal]

2001 BMJ Publishing Group Ltd. ;Copyright 2001 BMJ ;2002 INIST-CNRS ;Copyright: 2001 (c) 2001 BMJ Publishing Group Ltd. ;Copyright © 2001, BMJ 2001 ;ISSN: 0959-8138 ;ISSN: 0959-8146 ;EISSN: 1468-5833 ;EISSN: 1756-1833 ;DOI: 10.1136/bmj.323.7319.957 ;PMID: 11679383 ;CODEN: BMJOAE

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  • Title:
    Randomised trials of secondary prevention programmes in coronary heart disease: systematic review
  • Author: McAlister, Finlay A ; Lawson, Fiona M E ; Teo, Koon K ; Armstrong, Paul W
  • Subjects: Adrenergic beta-Antagonists - therapeutic use ; Biological and medical sciences ; Cardiology. Vascular system ; Cardiovascular disease ; Clinical trials ; Coronary artery disease ; Coronary Disease - mortality ; Coronary Disease - prevention & control ; Coronary heart disease ; Cost-Benefit Analysis ; Disease Management ; Disease risk ; Epidemiology ; Experimentation ; Health care ; Heart ; Heart attacks ; Heart diseases ; Hospital admissions ; Hospitalization ; Humans ; Hypolipidemic Agents - therapeutic use ; Medical sciences ; Mortality ; Myocardial infarction ; Nurses ; Pharmaceuticals ; Platelet Aggregation Inhibitors - therapeutic use ; Predisposing factors ; Prevention ; Quality of Life ; Randomized Controlled Trials as Topic ; Recurrence ; Risk ; Studies ; Treatment Outcome
  • Is Part Of: BMJ, 2001-10, Vol.323 (7319), p.957-962
  • Description: Abstract Objective: To determine whether multidisciplinary disease management programmes for patients with coronary heart disease improve processes of care and reduce morbidity and mortality. Data sources: Randomised clinical trials of disease management programmes in patients with coronary heart disease were identified by searching Medline 1966-2000, Embase 1980-99, CINAHL 1982-99, SIGLE 1980-99, the Cochrane controlled trial register, the Cochrane effective practice and organisation of care study register, and bibliographies of published studies. Data extraction: Studies were selected and data were extracted independently by two investigators, and summary risk ratios were calculated by using both the random effects model and the fixed effects model. Data synthesis: A total of 12 trials (9803 patients with coronary heart disease) were identified. Disease management programmes had positive impacts on processes of care. Patients randomised to these programmes were more likely to be prescribed efficacious drugs (risk ratio 2.14 (95% confidence interval 1.92 to 2.38) for lipid lowering drugs, 1.19 (1.07 to 1.32) for β blockers, and 1.07 (1.03 to 1.11) for antiplatelet agents). Five out of seven trials evaluating risk factor profiles showed significantly greater improvements with these programmes in comparison with usual care (with effect sizes in the moderate range). Summary risk ratios were 0.91 (0.79 to 1.04) for all cause mortality, 0.94 (0.80 to 1.10) for recurrent myocardial infarction, and 0.84 (0.76 to 0.94) for admission to hospital. Five of the eight trials evaluating quality of life or functional status reported better outcomes in the intervention arms. Only three of these trials reported the costs of the intervention—the interventions were cost saving in two cases. Conclusions: Disease management programmes improve processes of care, reduce admissions to hospital, and enhance quality of life or functional status in patients with coronary heart disease. The programmes' impact on survival and recurrent infarctions, their cost effectiveness, and the optimal mix of components remain uncertain. What is already known on this topic Evidence based cardiac rehabilitation programmes of varying intensity improve morbidity and mortality in survivors of myocardial infarction Patients with coronary heart disease are increasingly referred to multidisciplinary clinics that use disease management approaches What this study adds Disease management approaches have a positive impact on processes of care (prescription of proved efficacious drugs and cardiovascular risk profiles of patients) Most of the trials reported that quality of life or functional status was better in patients treated with disease management rather than usual care The optimal mix of components and the cost effectiveness of these programmes is still uncertain
  • Publisher: London: British Medical Journal Publishing Group
  • Language: English
  • Identifier: ISSN: 0959-8138
    ISSN: 0959-8146
    EISSN: 1468-5833
    EISSN: 1756-1833
    DOI: 10.1136/bmj.323.7319.957
    PMID: 11679383
    CODEN: BMJOAE
  • Source: AUTh Library subscriptions: ProQuest Central
    MEDLINE
    Alma/SFX Local Collection
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