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Co-delivery of Dexamethasone and Green Tea Polyphenols Using Electrospun Ultrafine Fibers for Effective Treatment of Keloid

Pharmaceutical research, 2014-07, Vol.31 (7), p.1632-1643 [Peer Reviewed Journal]

Springer Science+Business Media New York 2014 ;ISSN: 0724-8741 ;EISSN: 1573-904X ;DOI: 10.1007/s11095-013-1266-2 ;PMID: 24395405

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Title:
Co-delivery of Dexamethasone and Green Tea Polyphenols Using Electrospun Ultrafine Fibers for Effective Treatment of Keloid
Author: Li, Jinrong ; Fu, Rong ; Li, Long ; Yang, Guang ; Ding, Shan ; Zhong, Zhendong ; Zhou, Shaobing
Subjects: Administration, Topical ; Animals ; Anti-Bacterial Agents - administration & dosage ; Anti-Bacterial Agents - therapeutic use ; Anti-Inflammatory Agents - administration & dosage ; Anti-Inflammatory Agents - therapeutic use ; Bacterial infections ; Bandages ; Biochemistry ; Biomedical and Life Sciences ; Biomedical Engineering and Bioengineering ; Biomedicine ; Cells, Cultured ; Dexamethasone - administration & dosage ; Dexamethasone - therapeutic use ; Drug delivery systems ; Drug Delivery Systems - methods ; Drug therapy ; Fibers ; Humans ; Keloid - drug therapy ; Keloid - pathology ; Lactic Acid - chemistry ; Medical Law ; Mice ; Mice, Nude ; Nanofibers - chemistry ; Nanofibers - ultrastructure ; Pharmacology/Toxicology ; Pharmacy ; Polyglycolic Acid - chemistry ; Polymers ; Polyphenols - administration & dosage ; Polyphenols - therapeutic use ; Research Paper ; Skin - drug effects ; Skin - pathology ; Tea ; Tea - chemistry
Is Part Of: Pharmaceutical research, 2014-07, Vol.31 (7), p.1632-1643
Description: Purpose The electrospun polymer ultrafine fiber meshes wereused to co-deliver dexamethasone (DEX) and green tea polyphenols (GTP) in order to acquire a suitable balance between effective treament of keloid and safety to the skin. Methods This co-delivery system was prepared with a simple electrospinning technology. Keloid model was established on the back of athymic nude mice with the human keloid tissues and the formulated fiber meshes were applied onto keloids for an in vivo evaluation on their therapeutic effects. Results Unlike other therapeutic formulations, these fiber meshes as a new surgical dressing possess multiple useful functions, including the capabilities of maintaining a moist environment, resisting bacterial infection and controlling the drug release. Hydrophobic DEX molecules inside the fiber meshes can be released successfully from the channels formed by the early release of the hydrophilic GTP molecules and then transported across the skin. A distinctive result acquired from histological analysis shows that after 3-month treatment, the DEX/GTP-loaded fiber meshes significantly induce the degradation of collagen fibers in keloid on the back of nude mice compared to the traditional treatment. Conclusion The dressing formulation based on nanofibers provides a promising platform for the treatment of keloid.
Publisher: Boston: Springer US
Language: English
Identifier: ISSN: 0724-8741
EISSN: 1573-904X
DOI: 10.1007/s11095-013-1266-2
PMID: 24395405
Source: MEDLINE
Alma/SFX Local Collection
ProQuest Central

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Co-delivery of Dexamethasone and Green Tea Polyphenols Using Electrospun Ultrafine Fibers for Effective Treatment of Keloid

Springer Science+Business Media New York 2014 ;ISSN: 0724-8741 ;EISSN: 1573-904X ;DOI: 10.1007/s11095-013-1266-2 ;PMID: 24395405

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