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Breast Cancer Risk Genes — Association Analysis in More than 113,000 Women

The New England journal of medicine, 2021-02, Vol.384 (5), p.428-439 [Peer Reviewed Journal]

Copyright © 2021 Massachusetts Medical Society. All rights reserved. ;Copyright © 2021 Massachusetts Medical Society. ;COPYRIGHT 2021 Massachusetts Medical Society ;ISSN: 0028-4793 ;ISSN: 1533-4406 ;EISSN: 1533-4406 ;DOI: 10.1056/NEJMoa1913948 ;PMID: 33471991

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Title:
Breast Cancer Risk Genes — Association Analysis in More than 113,000 Women
Author: Dorling, Leila ; Carvalho, Sara ; Allen, Jamie ; González-Neira, Anna ; Fortuno, Cristina ; Dennis, Joe ; Alonso, M Rosario ; Álvarez, Nuria ; Osorio, Ana ; Harrington, Patricia A ; Baynes, Caroline ; Conroy, Don M ; Fachal, Laura ; Aittomäki, Kristiina ; Antonenkova, Natalia N ; Behrens, Sabine ; Białkowska, Katarzyna ; Bogdanova-Markov, Nadja ; Bonanni, Bernardo ; Bremer, Michael ; Briceno, Ignacio ; Burwinkel, Barbara ; Cameron, David A ; Camp, Nicola J ; Campbell, Archie ; Castelao, Jose E ; Cessna, Melissa H ; Chanock, Stephen J ; Collée, J Margriet ; Czene, Kamila ; Ekici, Arif B ; Fasching, Peter A ; Försti, Asta ; Glendon, Gord ; Garcia, Encarna B Gómez ; Alnæs, Grethe I Grenaker ; Haeberle, Lothar ; Hall, Per ; Harkness, Elaine F ; Hartikainen, Jaana M ; Heemskerk-Gerritsen, Bernadette A M ; Hillemanns, Peter ; Hogervorst, Frans B L ; Hollestelle, Antoinette ; Ho, Weang Kee ; Hooning, Maartje J ; Howell, Anthony ; Humphreys, Keith ; Idris, Faiza ; Jakubowska, Anna ; Jung, Audrey ; Khusnutdinova, Elza ; Kristensen, Vessela N ; Lakeman, Inge M M ; Lee, Min Hyuk ; Li, Jingmei ; Loizidou, Maria A ; Lubiński, Jan ; Mannermaa, Arto ; Manoochehri, Mehdi ; Manoukian, Siranoush ; Martinez, Maria Elena ; Maurer, Tabea ; Meindl, Alfons ; Michailidou, Kyriaki ; Miller, Nicola ; Mohd Taib, Nur Aishah ; Muir, Kenneth ; Nevanlinna, Heli ; Nordestgaard, Børge G ; Oosterwijk, Jan C ; Park, Sue K ; Park-Simon, Tjoung-Won ; Peterlongo, Paolo ; Porteous, David J ; Prajzendanc, Karolina ; Prokofyeva, Darya ; Radice, Paolo ; Rhenius, Valerie ; Rookus, Matti A ; Sawyer, Elinor J ; Shah, Mitul ; Southey, Melissa C ; Tomlinson, Ian ; Truong, Thérèse ; van den Ouweland, Ans M W ; van der Kolk, Lizet E ; Wendt, Camilla ; Yang, Xiaohong R ; Evans, D Gareth ; Simard, Jacques ; Borg, Åke ; Chang-Claude, Jenny ; García-Closas, Montserrat ; Milne, Roger L ; Pharoah, Paul D P ; Schmidt, Marjanka K ; Spurdle, Amanda B ; Vreeswijk, Maaike P G ; Kvist, Anders
Subjects: Adolescent ; Adult ; Age ; Age Factors ; Aged ; Aged, 80 and over ; Association analysis ; Bayesian analysis ; BRCA1 protein ; BRCA2 protein ; Breast cancer ; Breast Neoplasms - genetics ; Cancer and Oncology ; Cancer och onkologi ; Clinical Medicine ; Confidence intervals ; Estimates ; Estrogen receptors ; Family medical history ; Female ; Genetic aspects ; Genetic counseling ; Genetic Predisposition to Disease - genetics ; Genetic screening ; Genetic Variation ; Genome-wide association studies ; Humans ; Klinisk medicin ; Logistic Models ; Medical and Health Sciences ; Medicin och hälsovetenskap ; Middle Aged ; Mutation, Missense ; Odds Ratio ; p53 Protein ; Pathogenicity ; Population ; Proteins ; Risk ; Sequence Analysis, DNA ; Statistical analysis ; Tumors ; Womens health ; Young Adult
Is Part Of: The New England journal of medicine, 2021-02, Vol.384 (5), p.428-439
Description: Breast cancer risk has been attributed to variation in many genes, and gene panels for clinical testing are correspondingly large. But how much risk can be reliably attributed to variation in specific genes? This large study provides answers.
Publisher: United States: Massachusetts Medical Society
Language: English
Identifier: ISSN: 0028-4793
ISSN: 1533-4406
EISSN: 1533-4406
DOI: 10.1056/NEJMoa1913948
PMID: 33471991
Source: ProQuest One Psychology
AUTh Library subscriptions: ProQuest Central
MEDLINE
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Breast Cancer Risk Genes — Association Analysis in More than 113,000 Women

Copyright © 2021 Massachusetts Medical Society. All rights reserved. ;Copyright © 2021 Massachusetts Medical Society. ;COPYRIGHT 2021 Massachusetts Medical Society ;ISSN: 0028-4793 ;ISSN: 1533-4406 ;EISSN: 1533-4406 ;DOI: 10.1056/NEJMoa1913948 ;PMID: 33471991

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