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Associations of Pentraxin 3 With Cardiovascular Disease and All-Cause Death : The Cardiovascular Health Study

Arteriosclerosis, thrombosis, and vascular biology, 2009-04, Vol.29 (4), p.594-599 [Peer Reviewed Journal]

2009 INIST-CNRS ;ISSN: 1079-5642 ;EISSN: 1524-4636 ;DOI: 10.1161/ATVBAHA.108.178947 ;PMID: 19164811 ;CODEN: ATVBFA

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Title:
Associations of Pentraxin 3 With Cardiovascular Disease and All-Cause Death : The Cardiovascular Health Study
Author: SWORDS JENNY, Nancy ; ARNOLD, Alice M ; KULLER, Lewis H ; TRACY, Russell P ; PSATY, Bruce M
Subjects: Aged ; Atherosclerosis (general aspects, experimental research) ; Biological and medical sciences ; Biomarkers - blood ; Blood and lymphatic vessels ; C-Reactive Protein - analysis ; Cardiology. Vascular system ; Cardiovascular Diseases - blood ; Cardiovascular Diseases - etiology ; Cardiovascular Diseases - mortality ; Case-Control Studies ; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous ; Female ; Health Surveys ; Humans ; Inflammation Mediators - blood ; Linear Models ; Male ; Medical sciences ; Neuropharmacology ; Pharmacology. Drug treatments ; Predictive Value of Tests ; Proportional Hazards Models ; Prospective Studies ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) ; Psychology. Psychoanalysis. Psychiatry ; Psychopharmacology ; Risk Assessment ; Risk Factors ; Serum Amyloid P-Component - analysis ; Time Factors ; United States - epidemiology ; Up-Regulation
Is Part Of: Arteriosclerosis, thrombosis, and vascular biology, 2009-04, Vol.29 (4), p.594-599
Description: We examined associations of pentraxin 3 (PTX3), a vascular inflammation marker, with incident cardiovascular disease (CVD) and all-cause death. 1583 Cardiovascular Health Study participants free of prevalent CVD were included. Nonexclusive case groups were angina (n=476), myocardial infarction (MI; n=237), stroke (n=310), CVD death (n=282), and all-cause death (n=772). 535 participants had no events. PTX3 levels were higher in those with subclinical CVD (1.90+/-1.89 ng/mL) than those without (1.71+/-1.88 ng/mL; P=0.001). Using Cox regression adjusted for age, sex, and ethnicity, a standard deviation increase in PTX3 (1.89 ng/mL) was associated with CVD death (hazard ratio 1.11; 95% confidence interval 1.02 to 1.21) and all-cause death (1.08; 1.02 to 1.15). PTX3 was not associated with angina (1.09; 0.98 to 1.20), MI (0.96; 0.81 to 1.12), or stroke (1.06; 0.95 to 1.18). Adding C-reactive protein (CRP) or CVD risk factors to the models had no significant effects on associations. In these older adults, PTX3 was associated with CVD and all-cause death independent of CRP and CVD risk factors. PTX3 likely reflects different aspects of inflammation than CRP and may provide insight into vascular health in aging and chronic diseases of aging that lead to death.
Publisher: Philadelphia, PA: Lippincott Williams & Wilkins
Language: English
Identifier: ISSN: 1079-5642
EISSN: 1524-4636
DOI: 10.1161/ATVBAHA.108.178947
PMID: 19164811
CODEN: ATVBFA
Source: GFMER Free Medical Journals
MEDLINE
Alma/SFX Local Collection

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Associations of Pentraxin 3 With Cardiovascular Disease and All-Cause Death : The Cardiovascular Health Study

2009 INIST-CNRS ;ISSN: 1079-5642 ;EISSN: 1524-4636 ;DOI: 10.1161/ATVBAHA.108.178947 ;PMID: 19164811 ;CODEN: ATVBFA

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