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Integration of Light- and Brassinosteroid-Signaling Pathways by a GATA Transcription Factor in Arabidopsis

Developmental cell, 2010-12, Vol.19 (6), p.872-883 [Peer Reviewed Journal]

2010 Elsevier Inc. ;2015 INIST-CNRS ;Copyright © 2010 Elsevier Inc. All rights reserved. ;ISSN: 1534-5807 ;EISSN: 1878-1551 ;DOI: 10.1016/j.devcel.2010.10.023 ;PMID: 21145502

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Title:
Integration of Light- and Brassinosteroid-Signaling Pathways by a GATA Transcription Factor in Arabidopsis
Author: Luo, Xiao-Min ; Lin, Wen-Hui ; Zhu, Shengwei ; Zhu, Jia-Ying ; Sun, Yu ; Fan, Xi-Ying ; Cheng, Menglin ; Hao, Yaqi ; Oh, Eunkyoo ; Tian, Miaomiao ; Liu, Lijing ; Zhang, Ming ; Xie, Qi ; Chong, Kang ; Wang, Zhi-Yong
Subjects: Arabidopsis ; Arabidopsis - genetics ; Arabidopsis - metabolism ; Arabidopsis - radiation effects ; Arabidopsis Proteins - metabolism ; Base Sequence ; Binding Sites - genetics ; Biological and medical sciences ; Brassinosteroids ; Cell differentiation, maturation, development, hematopoiesis ; Cell physiology ; DNA Primers - genetics ; Fundamental and applied biological sciences. Psychology ; GATA2 Transcription Factor - genetics ; GATA2 Transcription Factor - metabolism ; Gene Expression Regulation, Plant ; Genes, Plant ; Light ; MicroRNAs - genetics ; Models, Biological ; Molecular and cellular biology ; Mutation ; Nuclear Proteins - metabolism ; Phototrophic Processes - genetics ; Phototrophic Processes - physiology ; Phototrophic Processes - radiation effects ; Plant Growth Regulators - metabolism ; Plants, Genetically Modified ; Promoter Regions, Genetic ; RNA, Plant - genetics ; Signal Transduction ; Steroids, Heterocyclic - metabolism ; Ubiquitin-Protein Ligases - metabolism
Is Part Of: Developmental cell, 2010-12, Vol.19 (6), p.872-883
Description: Light and brassinosteroid (BR) antagonistically regulate the developmental switch from etiolation in the dark to photomorphogenesis in the light in plants. Here, we identify GATA2 as a key transcriptional regulator that mediates the crosstalk between BR- and light-signaling pathways. Overexpression of GATA2 causes constitutive photomorphogenesis in the dark, whereas suppression of GATA2 reduces photomorphogenesis caused by light, BR deficiency, or the constitutive photomorphogenesis mutant cop1. Genome profiling and chromatin immunoprecipitation experiments show that GATA2 directly regulates genes that respond to both light and BR. BR represses GATA2 transcription through the BR-activated transcription factor BZR1, whereas light causes accumulation of GATA2 protein and feedback inhibition of GATA2 transcription. Dark-induced proteasomal degradation of GATA2 is dependent on the COP1 E3 ubiquitin ligase, and COP1 can ubiquitinate GATA2 in vitro. This study illustrates a molecular framework for antagonistic regulation of gene expression and seedling photomorphogenesis by BR and light. [Display omitted] ► GATA2 is a transcription factor that positively regulates photomorphogenesis ► GATA2 transcription is repressed by the BR-activated transcription factor BZR1 ► GATA2 protein is stabilized by light and mutations of the COP1 E3 ligase ► GATA2 interacts with COP1 and is ubiquitinated by COP1 in vitro
Publisher: Cambridge, MA: Elsevier Inc
Language: English
Identifier: ISSN: 1534-5807
EISSN: 1878-1551
DOI: 10.1016/j.devcel.2010.10.023
PMID: 21145502
Source: Cell Press Free Archives
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Integration of Light- and Brassinosteroid-Signaling Pathways by a GATA Transcription Factor in Arabidopsis

2010 Elsevier Inc. ;2015 INIST-CNRS ;Copyright © 2010 Elsevier Inc. All rights reserved. ;ISSN: 1534-5807 ;EISSN: 1878-1551 ;DOI: 10.1016/j.devcel.2010.10.023 ;PMID: 21145502

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