skip to main content
Language:
Search Limited to: Search Limited to: Resource type Show Results with: Show Results with: Search type Index

Human chorionic gonadotropin, angiogenic factors, and preeclampsia risk: a nested case-control study

Acta obstetricia et gynecologica Scandinavica, 2014-05, Vol.93 (5), p.454-462 [Peer Reviewed Journal]

2014 Nordic Federation of Societies of Obstetrics and Gynecology ;2014 Nordic Federation of Societies of Obstetrics and Gynecology. ;ISSN: 0001-6349 ;EISSN: 1600-0412 ;DOI: 10.1111/aogs.12363 ;PMID: 24575980 ;CODEN: AOGSAE

Full text available

Citations Cited by
  • Title:
    Human chorionic gonadotropin, angiogenic factors, and preeclampsia risk: a nested case-control study
  • Author: Åsvold, Bjørn O. ; Eskild, Anne ; Vatten, Lars J.
  • Subjects: Adult ; angiogenesis ; Biomarkers - blood ; Case-Control Studies ; Chorionic Gonadotropin - blood ; Female ; Gestational Age ; Human chorionic gonadotropin ; Humans ; hypertension in pregnancy ; Norway - epidemiology ; Placenta Growth Factor ; placental growth factor ; Pre-Eclampsia - blood ; Pre-Eclampsia - epidemiology ; preeclampsia ; Pregnancy ; Pregnancy Proteins - blood ; Pregnancy Trimesters ; Premature Birth - blood ; Premature Birth - epidemiology ; Risk Factors ; soluble fms-like tyrosine kinase 1 ; Vascular Endothelial Growth Factor Receptor-1 - blood ; Young Adult
  • Is Part Of: Acta obstetricia et gynecologica Scandinavica, 2014-05, Vol.93 (5), p.454-462
  • Description: Objective To study whether human chorionic gonadotropin concentrations during pregnancy or combinations of human chorionic gonadotropin and other angiogenic factors, soluble fms‐like tyrosine kinase 1 and placental growth factor (PlGF), are associated with preeclampsia risk. Design Nested case–control study. Setting Population cohort of pregnant women. Sample A total of 121 cases of preterm (<37 weeks) and 158 cases of term preeclampsia (≥37 weeks of gestation) and 356 women without preeclampsia (controls). Methods Women with preeclampsia were identified by linkage to the Medical Birth Registry of Norway. Concentrations of human chorionic gonadotropin, soluble fms‐like tyrosine kinase 1 and PlGF were measured in maternal serum samples collected in each trimester of pregnancy. Main outcome measures Odds ratios of preterm and term preeclampsia. Results High human chorionic gonadotropin concentrations (highest quartile) in the first trimester were associated with reduced risk for preterm preeclampsia (OR 0.3, 95% CI 0.1–0.9), compared with low human chorionic gonadotropin (lowest quartile), whereas high human chorionic gonadotropin concentrations in the second trimester were associated with increased risk for preterm preeclampsia (OR 4.0, 95% CI 1.8–8.9). High human chorionic gonadotropin concentrations in the third trimester were associated with increased risk for term preeclampsia (OR 4.8, 95% CI 1.8–13.3). Concentrations of human chorionic gonadotropin above the median value combined with PlGF below the median in the second trimester were associated with very high risk for preterm preeclampsia (OR 36.9, 95% CI 8.2–165.8). Conclusions The results suggest an important role of human chorionic gonadotropin in the pathophysiological processes that lead to preeclampsia. The combined association of human chorionic gonadotropin and PlGF indicates a possible synergism between underlying biological pathways.
  • Publisher: United States: Blackwell Publishing Ltd
  • Language: English;French;German
  • Identifier: ISSN: 0001-6349
    EISSN: 1600-0412
    DOI: 10.1111/aogs.12363
    PMID: 24575980
    CODEN: AOGSAE
  • Source: Journals@Ovid Open Access Journal Collection Rolling
    MEDLINE
    Alma/SFX Local Collection
Back to results list
INSPIRE LIBRARY - TON DUC THANG UNIVERSITY (84-028) 37 755 057 Feedback
19 Nguyen Huu Tho St. Dist.7, HCM thuvien@tdtu.edu.vn

Copyright © 2017 INSPIRE LIBRARY - TON DUC THANG UNIVERSITY

Searching Remote Databases, Please Wait