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OPA1 in Lipid Metabolism: Function of OPA1 in Lipolysis and Thermogenesis of Adipocytes

Hormone and metabolic research, 2017-04 [Peer Reviewed Journal]

info:eu-repo/semantics/openAccess ;ISSN: 0018-5043 ;EISSN: 1439-4286 ;DOI: 10.1055/s-0043-100384

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  • Title:
    OPA1 in Lipid Metabolism: Function of OPA1 in Lipolysis and Thermogenesis of Adipocytes
  • Author: Chu, Dinh Toi ; Tao, Yang ; Tasken, Kjetil
  • Is Part Of: Hormone and metabolic research, 2017-04
  • Description: OPA1 (Optic Atrophy 1) is a mitochondrial GTPase known to regulate fission of mitochondria. It was recently also shown to locate on lipid droplets in adipocytes where it functions as an A-kinase anchoring protein (AKAP) that mediates adrenergic control of lipolysis by facilitating PKA phosphorylation of perilipin (Plin1). In brown adipocytes indirect evidence support the notion that OPA1 regulation of fission serves to increase thermogenesis, which thereby contributes to dissipation of energy. In white adipocytes, OPA1 located on lipid droplets serves as a gatekeeper to control lipolysis induced by adrenergic agonists. However, the function of OPA1 in lipolysis and thermogenesis in inducible brown adipocytes (brite/beige cells) remains elusive. Here we discuss the role of OPA1 in lipid metabolism.
  • Publisher: Thieme Medical Publishers
  • Language: Norwegian
  • Identifier: ISSN: 0018-5043
    EISSN: 1439-4286
    DOI: 10.1055/s-0043-100384
  • Source: NORA Norwegian Open Research Archives
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