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Effectiveness and Safety of SARS-CoV-2 Vaccines among Children and Adolescents: A Systematic Review and Meta-Analysis

Vaccines (Basel), 2022-03, Vol.10 (3), p.421 [Peer Reviewed Journal]

2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2022 by the authors. 2022 ;ISSN: 2076-393X ;EISSN: 2076-393X ;DOI: 10.3390/vaccines10030421 ;PMID: 35335053

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  • Title:
    Effectiveness and Safety of SARS-CoV-2 Vaccines among Children and Adolescents: A Systematic Review and Meta-Analysis
  • Author: Gao, Peng ; Cai, Shan ; Liu, Qiao ; Du, Min ; Liu, Jue ; Liu, Min
  • Subjects: Adolescents ; Adverse events ; Anorexia ; Bias ; Children ; Chills ; Coronaviruses ; COVID-19 ; COVID-19 vaccines ; Drug dosages ; effectiveness ; Fatigue ; Headache ; Immunization ; Infections ; Injection ; Meta-analysis ; Muscles ; Myalgia ; Pain ; Pandemics ; Safety ; SARS-CoV-2 ; Severe acute respiratory syndrome ; Severe acute respiratory syndrome coronavirus 2 ; Statistical analysis ; Systematic Review ; Teenagers ; vaccine ; Vaccines ; Viral diseases
  • Is Part Of: Vaccines (Basel), 2022-03, Vol.10 (3), p.421
  • Description: Background: The proportion of children and adolescents with COVID-19 had gradually increased according to data reported by WHO. However, there was no meta-analysis of effectiveness and safety of SARS-CoV-2 vaccines in children and adolescents. We aimed to provide investigation-based medical evidence and reference recommendations for children and adolescents in regard to SARS-CoV-2 vaccines. Methods: We systematically searched PubMed, Embase, and Web of Science from inception to 5 January 2022. RCTs and observational studies that examined the effectiveness and safety were included. Results: A total of 13 eligible studies were included for analysis. For the first dose, the effectiveness of SARS-CoV-2 vaccines against SARS-CoV-2 infection and COVID-19 was 88.5% (95% CI:15.7−98.4%, p = 0.033) and 84.3% (95% CI: 66.6−92.6%, p < 0.001) separately. For the second dose, the effectiveness against SARS-CoV-2 infection and COVID-19 was 91.6% (95% CI: 37.8−99.5%, p = 0.083) and 92.7 (95% CI: 82.2−97.0, p < 0.001) separately. Injection-site pain, fatigue, headache, anorexia, and axillary swelling were the top five adverse events after the first dose of SARS-CoV-2 vaccines. Fatigue, injection-site pain, headache, chills, and myalgia/muscle pain were the top five adverse events after the second dose of SARS-CoV-2 vaccines. Conclusions: SARS-CoV-2 vaccines had good effectiveness and safety in children and adolescents. We suggest that children and adolescents should get vaccinated as soon as possible to protect themselves and slow the spread of the pandemic.
  • Publisher: Switzerland: MDPI AG
  • Language: English
  • Identifier: ISSN: 2076-393X
    EISSN: 2076-393X
    DOI: 10.3390/vaccines10030421
    PMID: 35335053
  • Source: PubMed Central
    Coronavirus Research Database
    ROAD: Directory of Open Access Scholarly Resources
    ProQuest Central
    DOAJ Directory of Open Access Journals
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