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Meta-Analysis on the Use of Zidovudine and Interferon-Alfa in Adult T-Cell Leukemia/Lymphoma Showing Improved Survival in the Leukemic Subtypes

Journal of clinical oncology, 2010-09, Vol.28 (27), p.4177-4183 [Tạp chí có phản biện]

2015 INIST-CNRS ;Distributed under a Creative Commons Attribution 4.0 International License ;ISSN: 0732-183X ;EISSN: 1527-7755 ;DOI: 10.1200/JCO.2010.28.0669 ;PMID: 20585095

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Meta-Analysis on the Use of Zidovudine and Interferon-Alfa in Adult T-Cell Leukemia/Lymphoma Showing Improved Survival in the Leukemic Subtypes
Tác giả: BAZARBACHI, Ali ; PLUMELLE, Yves ; RAMOS, Juan Carlos ; TORTEVOYE, Patricia ; OTROCK, Zaher ; TAYLOR, Graham ; GESSAIN, Antoine ; HARRINGTON, William ; PANELATTI, Gérard ; HERMINE, Olivier
Chủ đề: Adolescent ; Adult ; Aged ; Aged, 80 and over ; Antineoplastic Combined Chemotherapy Protocols ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Antiviral Agents ; Antiviral Agents - administration & dosage ; Biological and medical sciences ; Chi-Square Distribution ; Female ; Great Britain ; Hematologic and hematopoietic diseases ; Humans ; Interferon-alpha ; Interferon-alpha - administration & dosage ; Kaplan-Meier Estimate ; Kaplan-Meiers Estimate ; Leukemia-Lymphoma, Adult T-Cell ; Leukemia-Lymphoma, Adult T-Cell - drug therapy ; Leukemia-Lymphoma, Adult T-Cell - mortality ; Leukemia-Lymphoma, Adult T-Cell - pathology ; Leukemia-Lymphoma, Adult T-Cell - virology ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Life Sciences ; Male ; Martinique ; Medical sciences ; Microbiology and Parasitology ; Middle Aged ; Proportional Hazards Models ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Survivors ; Survivors - statistics & numerical data ; Time Factors ; Treatment Outcome ; Tumors ; United Kingdom ; United States ; Young Adult ; Zidovudine ; Zidovudine - administration & dosage
Là 1 phần của: Journal of clinical oncology, 2010-09, Vol.28 (27), p.4177-4183
Mô tả: Human T-cell lymphotropic virus type-I-associated adult T-cell leukemia/lymphoma (ATL) is an aggressive, chemotherapy-resistant malignancy. Multiple small studies using zidovudine (AZT) and interferon-alfa (IFN-α) have shown response in patients with ATL. However, the impact of this innovative antiviral treatment strategy on long-term survival remains undetermined. We report a meta-analysis of antiviral therapy of ATL. Medical records of 254 patients with ATL who were treated in the United States, the United Kingdom, Martinique, and continental France were individually reviewed. According to Shimoyama classification, there were 116 patients with acute ATL, 18 patients with chronic ATL, 11 patients with smoldering ATL, and 100 patients with ATL lymphoma. In 231 patients with available survival data, first-line therapy was recorded in 207 patients. Five-year overall survival rates were 46% for 75 patients who received first-line antiviral therapy (P = .004), 20% for 77 patients who received first-line chemotherapy, and 12% for 55 patients who received first-line chemotherapy followed by antiviral therapy. Patients with acute, chronic, and smoldering ATL significantly benefited from first-line antiviral therapy, whereas patients with ATL lymphoma experienced a better outcome with chemotherapy. In acute ATL, achievement of complete remission with antiviral therapy resulted in 82% 5-year survival. Antiviral therapy in chronic and smoldering ATL resulted in 100% 5-year survival. Multivariate analysis confirmed that first-line antiviral therapy significantly improves overall survival of patients with ATL (hazard ratio, 0.47; 95% CI, 0.27 to 0.83; P = .021). These results confirm the high efficacy of AZT and IFN, which should now be considered the gold standard first-line therapy in leukemic subtypes of ATL.
Nơi xuất bản: Alexandria, VA: American Society of Clinical Oncology
Ngôn ngữ: English
Số nhận dạng: ISSN: 0732-183X
EISSN: 1527-7755
DOI: 10.1200/JCO.2010.28.0669
PMID: 20585095
Nguồn: Geneva Foundation Free Medical Journals at publisher websites
MEDLINE
Alma/SFX Local Collection

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Meta-Analysis on the Use of Zidovudine and Interferon-Alfa in Adult T-Cell Leukemia/Lymphoma Showing Improved Survival in the Leukemic Subtypes

2015 INIST-CNRS ;Distributed under a Creative Commons Attribution 4.0 International License ;ISSN: 0732-183X ;EISSN: 1527-7755 ;DOI: 10.1200/JCO.2010.28.0669 ;PMID: 20585095

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