Language:

Breath-Ammonia Testing of Healthy Subjects and Patients with Cirrhosis

Digestive diseases and sciences, 2012, Vol.57 (1), p.189-195 [Peer Reviewed Journal]

Springer Science+Business Media, LLC 2011 ;COPYRIGHT 2012 Springer ;Springer Science+Business Media, LLC 2012 ;ISSN: 0163-2116 ;EISSN: 1573-2568 ;DOI: 10.1007/s10620-011-1858-9 ;PMID: 21842240 ;CODEN: DDSCDJ

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Breath-Ammonia Testing of Healthy Subjects and Patients with Cirrhosis
Author: Adrover, R. ; Cocozzella, D. ; Ridruejo, E. ; García, A. ; Rome, J. ; Podestá, J. J.
Subjects: Adult ; Aged ; Ammonia ; Ammonia - metabolism ; Biochemistry ; Breath Tests - instrumentation ; Breath Tests - methods ; Case-Control Studies ; Comorbidity ; Cost-Benefit Analysis ; Female ; Gastroenterology ; Hepatic Encephalopathy - diagnosis ; Hepatic Encephalopathy - etiology ; Hepatic Encephalopathy - metabolism ; Hepatology ; Humans ; Liver ; Liver cirrhosis ; Liver Cirrhosis - complications ; Liver Cirrhosis - epidemiology ; Liver Cirrhosis - metabolism ; Male ; Medical research ; Medicine ; Medicine & Public Health ; Medicine, Experimental ; Middle Aged ; Oncology ; Original Article ; Predictive Value of Tests ; ROC Curve ; Transplant Surgery
Is Part Of: Digestive diseases and sciences, 2012, Vol.57 (1), p.189-195
Description: Background Hepatic encephalopathy (HE) is a serious neuropsychiatric complication in both acute and chronic liver disease. Aims To establish the utility of a portable noninvasive method to measure ammonia in the breath of healthy subjects and patients with HE. Methods The study included 106 subjects: 44 women and 62 men, 51 healthy and 55 cirrhotic. The breath ammonia was measured with an electrochemical sensor and expressed in parts/billion (ppb). Results The breath ammonia in healthy subjects had an average value of 151.4 ppb (95% confidence interval [CI]: 149.4–153.4) and the average value in cirrhotic patients was 169.9 ppb (95% CI: 163.5–176.2) ( P < 0.0001). In cirrhotic patients with and without HE, the corresponding values were 184.1 ppb (95% CI: 167.7–200.6) and 162.9 ppb (95% CI: 158.8–167.0), respectively ( P = 0.0011). Ammonia levels ≥165 ppb permitted a differentiation between healthy and cirrhotic subjects; the area under the receiver operating characteristic (ROC) curve for the ammonia-level values in cirrhotic versus control patients was 0.86 (95% CI: 0.79–0.93). In cirrhotic patients, ammonia levels ≥175 ppb permitted the distinction between patients with and without HE; the area under the ROC curve in cirrhotic patients with versus without HE was 0.83 (95% CI: 0.73–0.94). Conclusion A portable sensor for measuring breath ammonia can be developed. If the results of the present study are confirmed, breath-ammonia determinations could produce a significant impact on the care of patients with cirrhosis and could even include the possibility of self-monitoring.
Publisher: Boston: Springer US
Language: English
Identifier: ISSN: 0163-2116
EISSN: 1573-2568
DOI: 10.1007/s10620-011-1858-9
PMID: 21842240
CODEN: DDSCDJ
Source: AUTh Library subscriptions: ProQuest Central
MEDLINE
Alma/SFX Local Collection

Back to results list

Previous Result 19 Next Go to Next page


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Breath-Ammonia Testing of Healthy Subjects and Patients with Cirrhosis

Springer Science+Business Media, LLC 2011 ;COPYRIGHT 2012 Springer ;Springer Science+Business Media, LLC 2012 ;ISSN: 0163-2116 ;EISSN: 1573-2568 ;DOI: 10.1007/s10620-011-1858-9 ;PMID: 21842240 ;CODEN: DDSCDJ

Searching Remote Databases, Please Wait