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Prevalence of Small Intestine Carcinoid Tumors: A US Population-Based Study 2012–2017

Digestive diseases and sciences, 2019-05, Vol.64 (5), p.1328-1334 [Peer Reviewed Journal]

Springer Science+Business Media, LLC, part of Springer Nature 2018 ;COPYRIGHT 2019 Springer ;Digestive Diseases and Sciences is a copyright of Springer, (2018). All Rights Reserved. ;ISSN: 0163-2116 ;EISSN: 1573-2568 ;DOI: 10.1007/s10620-018-5402-z ;PMID: 30519851

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Title:
Prevalence of Small Intestine Carcinoid Tumors: A US Population-Based Study 2012–2017
Author: Abou Saleh, Mohannad ; Mansoor, Emad ; Anindo, Mohammad ; Isenberg, Gerard
Subjects: Adult ; Aged ; Aged, 80 and over ; Biochemistry ; Carcinoid Tumor - diagnostic imaging ; Carcinoid Tumor - epidemiology ; Cohort Studies ; Diabetes ; Epidemiology ; Female ; Gastroenterology ; Gastrointestinal system ; Hepatology ; Humans ; Intestinal Neoplasms - diagnostic imaging ; Intestinal Neoplasms - epidemiology ; Intestine, Small - diagnostic imaging ; Male ; Medical research ; Medicine ; Medicine & Public Health ; Medicine, Experimental ; Middle Aged ; Oncology ; Original Article ; Population Surveillance - methods ; Prevalence ; Retrospective Studies ; Transplant Surgery ; Tumors ; United States - epidemiology
Is Part Of: Digestive diseases and sciences, 2019-05, Vol.64 (5), p.1328-1334
Description: Background and Aims Most carcinoid tumors of the gastrointestinal tract are located in the small bowel (SB). Epidemiological studies of these tumors have been limited by small sample sizes. Our aim was to evaluate the epidemiology of SB carcinoids (SBCs) using a large database. Methods We queried a commercial database (Explorys), an aggregate of electronic health data from 26 US healthcare systems. We identified patients with SBCs between 2012 and 2017. We evaluated the epidemiology of SBC and identified possible risk factors. Results Of the 35,798,290 individuals in the database between 2012 and 2017, we identified 3280 patients with SBCs, with a prevalence of 9.2/100,000. Prevalence was higher in men [odds ratio (OR) 1.23, 95% confidence interval (CI) 1.153–1.322, p < 0.0001], whites [OR 2.031, 95% CI 1.872–2.203, p < 0.0001], and elderly (aged > 65) [OR 4.856, 95% CI 4.533–5.203, p < 0.0001]. Patients with SBCs were more likely to have a history of smoking [OR 2.749, 95% CI 2.549–2.970, p < 0.0001], alcohol use [OR 2.031, 95% CI 1.864–2.21, p < 0.0001], obesity (BMI > 30) [OR 3.476, 95% CI 3.213–3.761, p < 0.0001], diabetes mellitus [OR 4.198, 95% CI 3.900–4.519, p < 0.0001], and a family history of cancer [OR 5.902, 95% CI 5.396–6.456, p < 0.0001]. Conclusions This is one of the largest studies done on the prevalence of SBC. The prevalence of 9.2/100,000 individuals is higher than previously reported. Further genetic and environmental studies are needed to understand the potential mechanisms for the risk factors identified in this study.
Publisher: New York: Springer US
Language: English
Identifier: ISSN: 0163-2116
EISSN: 1573-2568
DOI: 10.1007/s10620-018-5402-z
PMID: 30519851
Source: MEDLINE
ProQuest Central

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Prevalence of Small Intestine Carcinoid Tumors: A US Population-Based Study 2012–2017

Springer Science+Business Media, LLC, part of Springer Nature 2018 ;COPYRIGHT 2019 Springer ;Digestive Diseases and Sciences is a copyright of Springer, (2018). All Rights Reserved. ;ISSN: 0163-2116 ;EISSN: 1573-2568 ;DOI: 10.1007/s10620-018-5402-z ;PMID: 30519851

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