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Different Profile of Peripheral Antioxidant Enzymes and Lipid Peroxidation in Active and Non-active Inflammatory Bowel Disease Patients

Digestive diseases and sciences, 2013-05, Vol.58 (5), p.1244-1249 [Peer Reviewed Journal]

Springer Science+Business Media New York 2013 ;COPYRIGHT 2013 Springer ;Springer Science+Business Media, LLC 2013 ;ISSN: 0163-2116 ;EISSN: 1573-2568 ;DOI: 10.1007/s10620-012-2510-z ;PMID: 23306840 ;CODEN: DDSCDJ

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Title:
Different Profile of Peripheral Antioxidant Enzymes and Lipid Peroxidation in Active and Non-active Inflammatory Bowel Disease Patients
Author: Achitei, D. ; Ciobica, A. ; Balan, G. ; Gologan, E. ; Stanciu, C. ; Stefanescu, G.
Subjects: Adult ; Antioxidants ; Biochemistry ; C-Reactive Protein - metabolism ; Case-Control Studies ; Comparative analysis ; Female ; Gastroenterology ; Gastrointestinal diseases ; Glutathione Peroxidase - metabolism ; Hepatology ; Humans ; Inflammatory Bowel Diseases - enzymology ; Lipid Peroxidation ; Lipids ; Male ; Malondialdehyde - blood ; Medical colleges ; Medical research ; Medicine ; Medicine & Public Health ; Medicine, Experimental ; Middle Aged ; Oncology ; Original Article ; Oxidative Stress ; Peroxidase ; Prospective Studies ; Risk factors ; Superoxide ; Superoxide Dismutase - metabolism ; Transplant Surgery ; Young Adult
Is Part Of: Digestive diseases and sciences, 2013-05, Vol.58 (5), p.1244-1249
Description: Background The role of oxidative stress in inflammatory bowel diseases (IBD) has been extended lately from a simple consequence of inflammation to a potential etiological factor, but the data are still controversial. Active disease has been characterized before by an enhanced production of reactive oxygen species and the increased peroxidation of lipids, but patients in remission were generally not considered different from healthy people in terms of oxidative stress. Aims We evaluated the antioxidant defense capacity and lipid peroxidation status in the serum of patients with active and non-active disease compared with healthy matched control subjects. Methods The study included 20 patients with confirmed IBD in clinical and biological remission, 21 patients with active disease, and 18 controls. We determined the serum levels of two antioxidant enzymes, superoxide dismutase (SOD) and glutathione peroxidase (GPX), and a lipid peroxidation marker, malondialdehyde (MDA). Results Active disease patients had an increased activity of both SOD and GPX, as well as significant high values of MDA versus controls. Furthermore, patients being in remission had significantly lower values of antioxidant enzymes (SOD and GPX) and increased lipid peroxidation measured by MDA serum levels, as compared with healthy control subjects. Conclusions Our study confirmed the presence of high oxidative stress in active IBD. More importantly, we have demonstrated a lower antioxidant capacity of patients in remission versus control group. This may represent a risk factor for the disease and can be an additional argument for the direct implication of oxidative stress in the pathogenesis of IBD.
Publisher: Boston: Springer US
Language: English
Identifier: ISSN: 0163-2116
EISSN: 1573-2568
DOI: 10.1007/s10620-012-2510-z
PMID: 23306840
CODEN: DDSCDJ
Source: AUTh Library subscriptions: ProQuest Central
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Different Profile of Peripheral Antioxidant Enzymes and Lipid Peroxidation in Active and Non-active Inflammatory Bowel Disease Patients

Springer Science+Business Media New York 2013 ;COPYRIGHT 2013 Springer ;Springer Science+Business Media, LLC 2013 ;ISSN: 0163-2116 ;EISSN: 1573-2568 ;DOI: 10.1007/s10620-012-2510-z ;PMID: 23306840 ;CODEN: DDSCDJ

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