Language:

A population-based cohort study of rheumatoid arthritis-associated interstitial lung disease: comorbidity and mortality

Annals of the rheumatic diseases, 2017-10, Vol.76 (10), p.1700-1706 [Peer Reviewed Journal]

Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted. ;Copyright: 2017 © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted. ;ISSN: 0003-4967 ;EISSN: 1468-2060 ;DOI: 10.1136/annrheumdis-2017-211138 ;PMID: 28611082

Full text available

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
A population-based cohort study of rheumatoid arthritis-associated interstitial lung disease: comorbidity and mortality
Author: Hyldgaard, Charlotte ; Hilberg, Ole ; Pedersen, Alma Becic ; Ulrichsen, Sinna Pilgaard ; Løkke, Anders ; Bendstrup, Elisabeth ; Ellingsen, Torkell
Subjects: Age Factors ; Aged ; Arthritis, Rheumatoid - epidemiology ; Arthritis, Rheumatoid - immunology ; Arthritis, Rheumatoid - mortality ; Autoantibodies - blood ; Cardiovascular disease ; Case-Control Studies ; Comorbidity ; Death ; Denmark - epidemiology ; Female ; Gender ; Health risk assessment ; Hospitals ; Humans ; Identification ; Incidence ; Kaplan-Meier Estimate ; Lung diseases ; Lung Diseases, Interstitial - epidemiology ; Lung Diseases, Interstitial - mortality ; Male ; Middle Aged ; Mortality ; Pneumonia ; Population ; Population studies ; Prevalence ; Prospective Studies ; Pulmonary fibrosis ; Registries ; Regression analysis ; Rheumatoid arthritis ; Sex Factors ; Smoking ; Survival Rate
Is Part Of: Annals of the rheumatic diseases, 2017-10, Vol.76 (10), p.1700-1706
Description: ObjectivesTo compare mortality risks in patients with rheumatoid arthritis-associated interstitial lung disease (RA-ILD) and patients with RA without ILD.DesignMatched cohort study.SettingThe study was conducted in Denmark, using nationwide, prospectively collected data.ParticipantsAmong patients with RA diagnosed between 2004 and 2016, 679 patients with RA-ILD were matched for birth year, gender and age at RA diagnosis with 11 722 patients with RA but without ILD.Main outcome measuresMortality risks were assessed using Kaplan-Meier mortality curves, and hazard rate ratios (HRRs) for death were estimated using Cox proportional hazards regression models.ResultsThe number of prevalent RA patients more than doubled from 15 352 to 35 362 individuals during the study period. RA-ILD was seen in 2.2% of incident RA patients. 34.0% of RA-ILD cases were diagnosed within 1 year prior to and 1 year after the RA diagnosis. One-year mortality was 13.9% (95% CI, 11.4% to 16.7%) in RA-ILD and 3.8% (95% CI, 3.5% to 4.2%) in non-ILD RA, 5-year mortality was 39.0% (34.4% to 43.5%) and 18.2% (17.3% to 19.1%) and 10-year mortality was 60.1% (52.9% to 66.5%) and 34.5% (32.8% to 36.1%), respectively. The HRRs for death were 2 to 10 times increased for RA-ILD compared with non-ILD RA, irrespective of follow-up period. Stratified analysis showed that the HRR for death was highest in the first months after the diagnosis of RA-ILD was made, especially in patients diagnosed with RA before diagnosis of ILD. HRR was higher in males and in patients without comorbidity as assessed by the Charlson Comorbidity Index.ConclusionsILD is a serious complication in RA, with a significantly increased mortality compared with a large matched cohort of RA comparisons without ILD.
Publisher: England: BMJ Publishing Group LTD
Language: English
Identifier: ISSN: 0003-4967
EISSN: 1468-2060
DOI: 10.1136/annrheumdis-2017-211138
PMID: 28611082
Source: MEDLINE
ProQuest Central

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

A population-based cohort study of rheumatoid arthritis-associated interstitial lung disease: comorbidity and mortality

Searching Remote Databases, Please Wait