skip to main content
Language:
Search Limited to: Search Limited to: Resource type Show Results with: Show Results with: Search type Index

Defining insulin resistance from hyperinsulinemic-euglycemic clamps

Diabetes care, 2012-07, Vol.35 (7), p.1605-1610 [Peer Reviewed Journal]

COPYRIGHT 2012 American Diabetes Association ;Copyright American Diabetes Association Jul 2012 ;2012 by the American Diabetes Association. 2012 ;ISSN: 0149-5992 ;EISSN: 1935-5548 ;DOI: 10.2337/dc11-2339 ;PMID: 22511259 ;CODEN: DICAD2

Full text available

Citations Cited by
  • Title:
    Defining insulin resistance from hyperinsulinemic-euglycemic clamps
  • Author: Tam, Charmaine S ; Xie, Wenting ; Johnson, William D ; Cefalu, William T ; Redman, Leanne M ; Ravussin, Eric
  • Subjects: Adult ; Aged ; Body Mass Index ; Decision Trees ; Dextrose ; Diabetes ; Glucose ; Glucose Clamp Technique - methods ; Humans ; Hyperglycemia ; Insulin ; Insulin - blood ; Insulin Resistance ; Medical research ; Medicine, Experimental ; Middle Aged ; Models, Biological ; Original Research ; Reference Values ; Studies
  • Is Part Of: Diabetes care, 2012-07, Vol.35 (7), p.1605-1610
  • Description: This study was designed to determine a cutoff point for identifying insulin resistance from hyperinsulinemic-euglycemic clamp studies performed at 120 mU/m(2)·min in a white population and to generate equations from routinely measured clinic and blood variables for predicting clamp-derived glucose disposal rate (GDR), i.e., insulin sensitivity. We assembled data from hyperinsulinemic-euglycemic clamps (120 mU/m(2)·min insulin dose) performed at the Pennington Biomedical Research Center between 2001 and 2011. Subjects were divided into subjects with diabetes (n = 51) and subjects without diabetes (n = 116) by self-report and/or fasting glucose ≥126 mg/dL. We found that 75% of individuals with a GDR <5.6 mg/kg fat-free mass (FFM) + 17.7·min were truly insulin resistant. Cutoff values for GDRs normalized for body weight, body surface area, or FFM were 4.9 mg/kg·min, 212.2 mg/m(2)·min, and 7.3 mg/kgFFM·min, respectively. Next, we used classification tree models to predict GDR from routinely measured clinical and biochemical variables. We found that individual insulin resistance could be estimated with good sensitivity (89%) and specificity (67%) from the homeostasis model assessment of insulin resistance (HOMA-IR) >5.9 or 2.8< HOMA-IR <5.9 with HDL <51 mg/dL. We developed a cutoff for defining insulin resistance from hyperinsulinemic-euglycemic clamps. Moreover, we now provide classification trees for predicting insulin resistance from routinely measured clinical and biochemical markers. These findings extend the clamp from a research tool to providing a clinically meaningful message for participants in research studies, potentially providing greater opportunity for earlier recognition of insulin resistance.
  • Publisher: United States: American Diabetes Association
  • Language: English
  • Identifier: ISSN: 0149-5992
    EISSN: 1935-5548
    DOI: 10.2337/dc11-2339
    PMID: 22511259
    CODEN: DICAD2
  • Source: GFMER Free Medical Journals
    MEDLINE
    Alma/SFX Local Collection
    ProQuest Central
Back to results list
INSPIRE LIBRARY - TON DUC THANG UNIVERSITY (84-028) 37 755 057 Feedback
19 Nguyen Huu Tho St. Dist.7, HCM thuvien@tdtu.edu.vn

Copyright © 2017 INSPIRE LIBRARY - TON DUC THANG UNIVERSITY

Searching Remote Databases, Please Wait