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PPAR control of metabolism and cardiovascular functions

Nature reviews cardiology, 2021-12, Vol.18 (12), p.809-823 [Peer Reviewed Journal]

2021. Springer Nature Limited. ;COPYRIGHT 2021 Nature Publishing Group ;Springer Nature Limited 2021. ;Distributed under a Creative Commons Attribution 4.0 International License ;ISSN: 1759-5002 ;EISSN: 1759-5010 ;DOI: 10.1038/s41569-021-00569-6 ;PMID: 34127848

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Title:
PPAR control of metabolism and cardiovascular functions
Author: Montaigne, David ; Butruille, Laura ; Staels, Bart
Subjects: Cardiovascular diseases ; Cardiovascular Diseases - metabolism ; Cardiovascular Diseases - prevention & control ; Cardiovascular research ; Cardiovascular system ; Care and treatment ; Fatty acids ; Gene expression ; Humans ; Life Sciences ; Lipids ; Metabolic diseases ; Metabolic regulation ; Metabolism ; Physiology ; PPAR alpha - metabolism ; PPAR delta - metabolism ; PPAR gamma - metabolism
Is Part Of: Nature reviews cardiology, 2021-12, Vol.18 (12), p.809-823
Description: Peroxisome proliferator-activated receptor-α (PPARα), PPARδ and PPARγ are transcription factors that regulate gene expression following ligand activation. PPARα increases cellular fatty acid uptake, esterification and trafficking, and regulates lipoprotein metabolism genes. PPARδ stimulates lipid and glucose utilization by increasing mitochondrial function and fatty acid desaturation pathways. By contrast, PPARγ promotes fatty acid uptake, triglyceride formation and storage in lipid droplets, thereby increasing insulin sensitivity and glucose metabolism. PPARs also exert antiatherogenic and anti-inflammatory effects on the vascular wall and immune cells. Clinically, PPARγ activation by glitazones and PPARα activation by fibrates reduce insulin resistance and dyslipidaemia, respectively. PPARs are also physiological master switches in the heart, steering cardiac energy metabolism in cardiomyocytes, thereby affecting pathological heart failure and diabetic cardiomyopathy. Novel PPAR agonists in clinical development are providing new opportunities in the management of metabolic and cardiovascular diseases.
Publisher: England: Nature Publishing Group
Language: English
Identifier: ISSN: 1759-5002
EISSN: 1759-5010
DOI: 10.1038/s41569-021-00569-6
PMID: 34127848
Source: Hyper Article en Ligne (HAL) (Open Access)
MEDLINE
ProQuest Central

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PPAR control of metabolism and cardiovascular functions

2021. Springer Nature Limited. ;COPYRIGHT 2021 Nature Publishing Group ;Springer Nature Limited 2021. ;Distributed under a Creative Commons Attribution 4.0 International License ;ISSN: 1759-5002 ;EISSN: 1759-5010 ;DOI: 10.1038/s41569-021-00569-6 ;PMID: 34127848

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