Language:

Serious obstetric complications interact with hypoxia-regulated vascular-expression genes to influence schizophrenia risk

Molecular psychiatry, 2008-09, Vol.13 (9), p.873-877 [Peer Reviewed Journal]

2008 INIST-CNRS ;COPYRIGHT 2008 Nature Publishing Group ;Copyright Nature Publishing Group Sep 2008 ;Nature Publishing Group 2008. ;ISSN: 1359-4184 ;EISSN: 1476-5578 ;DOI: 10.1038/sj.mp.4002153 ;PMID: 18195713

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Serious obstetric complications interact with hypoxia-regulated vascular-expression genes to influence schizophrenia risk
Author: NICODEMUS, K. K ; MARENCO, S ; BATTEN, A. J ; VAKKALANKA, R ; EGAN, M. F ; STRAUB, R. E ; WEINBERGER, D. R
Subjects: Adult and adolescent clinical studies ; AKT1 protein ; Biological and medical sciences ; Brain-derived neurotrophic factor ; Diagnosis ; Epistasis ; Etiology ; Family Health ; Female ; Fetuses ; Gene Expression Regulation - physiology ; Genes ; Genetic aspects ; Humans ; Hypoxia ; Hypoxia-Ischemia, Brain - embryology ; Hypoxia-Ischemia, Brain - genetics ; Hypoxia-Ischemia, Brain - physiopathology ; Linkage Disequilibrium ; Logistic Models ; Male ; Medical sciences ; Mental disorders ; Obstetric Labor Complications ; Obstetrics ; Odds Ratio ; Physiological aspects ; Polymorphism, Single Nucleotide ; Pregnancy ; Proto-Oncogene Proteins c-akt - genetics ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychoses ; Risk Factors ; Schizophrenia ; Schizophrenia - etiology ; Schizophrenia - genetics ; Single-nucleotide polymorphism ; Surveys and Questionnaires ; Tumor necrosis factor-α
Is Part Of: Molecular psychiatry, 2008-09, Vol.13 (9), p.873-877
Description: The etiology of schizophrenia is thought to include both epistasis and gene-environment interactions. We sought to test whether a set of schizophrenia candidate genes regulated by hypoxia or involved in vascular function in the brain (AKT1, BDNF, CAPON, CHRNA7, COMT, DTNBP1, GAD1, GRM3, NOTCH4, NRG1, PRODH, RGS4, TNF-alpha) interacted with serious obstetric complications to influence risk for schizophrenia. A family-based study of transmission disequilibrium was conducted in 116 trios. Twenty-nine probands had at least one serious obstetric complication (OC) using the McNeil-Sjostrom Scale, and many of the OCs reported were associated with the potential for fetal hypoxia. Analyses were conducted using conditional logistic regression and a likelihood ratio test (LRT) between nested models was performed to assess significance. Of the 13 genes examined, four (AKT1 (three SNPs), BDNF (two SNPs), DTNBP1 (one SNP) and GRM3 (one SNP)) showed significant evidence for gene-by-environment interaction (LRT P-values ranged from 0.011 to 0.037). Although our sample size was modest and the power to detect interactions was limited, we report significant evidence for genes involved in neurovascular function or regulated by hypoxia interacting with the presence of serious obstetric complications to increase risk for schizophrenia.
Publisher: Basingstoke: Nature Publishing Group
Language: English
Identifier: ISSN: 1359-4184
EISSN: 1476-5578
DOI: 10.1038/sj.mp.4002153
PMID: 18195713
Source: ProQuest One Psychology
MEDLINE
ProQuest Central

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Serious obstetric complications interact with hypoxia-regulated vascular-expression genes to influence schizophrenia risk

2008 INIST-CNRS ;COPYRIGHT 2008 Nature Publishing Group ;Copyright Nature Publishing Group Sep 2008 ;Nature Publishing Group 2008. ;ISSN: 1359-4184 ;EISSN: 1476-5578 ;DOI: 10.1038/sj.mp.4002153 ;PMID: 18195713

Searching Remote Databases, Please Wait