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Aflibercept versus dexamethasone for macular edema secondary to central retinal vein occlusion
Medwave, 2019-12, Vol.19 (11), p.e7739-e7738
ISSN: 0717-6384 ;EISSN: 0717-6384 ;DOI: 10.5867/medwave.2019.11.7738 ;PMID: 31891353
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Title:
Aflibercept versus dexamethasone for macular edema secondary to central retinal vein occlusion
Author:
Garretón, Rodolfo
;
Gonzalez, Raul
Subjects:
aflibercept
;
dexamethasone
;
epistemonikos
;
grade
;
macular edema
Is Part Of:
Medwave, 2019-12, Vol.19 (11), p.e7739-e7738
Description:
Macular edema is a frequent complication of central retinal vein occlusion that might lead to deterioration of visual acuity. The most commonly used treatments are dexamethasone implant and anti-vascular endothelial growth factor drugs, being aflibercept one of the most commonly used them. However, there is no consensus about which treatment constitute the best alternative. We searched in Epistemonikos, the largest database of systematic reviews in health, which is maintained by screening multiple information sources, including MEDLINE, EMBASE, Cochrane, among others. We extracted data from the systematic reviews, reanalyzed data of primary studies, conducted a meta-analysis and generated a summary of findings table using the GRADE approach. We identified two systematic reviews that included four primary studies overall, all randomized trials. We concluded that it is not possible to establish whether aflibercept is superior to dexamethasone in terms of improvement of visual acuity and safety, because the certainty of the existing evidence has been evaluated as very low.
Publisher:
Chile: Medwave Estudios Limitada
Language:
Spanish;English
Identifier:
ISSN: 0717-6384
EISSN: 0717-6384
DOI: 10.5867/medwave.2019.11.7738
PMID: 31891353
Source:
DOAJ Directory of Open Access Journals
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