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Potential application of biomimetic exosomes in cardiovascular disease: focused on ischemic heart disease

BMB reports, 2022-01, Vol.55 (1), p.30-38 [Peer Reviewed Journal]

ISSN: 1976-6696 ;EISSN: 1976-670X

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  • Title:
    Potential application of biomimetic exosomes in cardiovascular disease: focused on ischemic heart disease
  • Author: Kang, In Sook ; Kwon, Kihwan
  • Subjects: Biomimetics ; Cardiovascular disease ; Exosome ; Extracellular vesicles ; Regenerative medicine
  • Is Part Of: BMB reports, 2022-01, Vol.55 (1), p.30-38
  • Description: Cardiovascular disease, especially ischemic heart disease, is a major cause of mortality worldwide. Cardiac repair is one of the most promising strategies to address advanced cardiovascular diseases. Despite moderate improvement in heart function via stem cell therapy, there is no evidence of significant improvement in mortality and morbidity beyond standard therapy. The most salutary effect of stem cell therapy are attributed to the paracrine effects and the stem cell-derived exosomes are known as a major contributor. Hence, exosomes are emerging as a promising therapeutic agent and potent biomarkers of cardiovascular disease. Furthermore, they play a role as cellular cargo and facilitate intercellular communication. However, the clinical use of exosomes is hindered by the absence of a standard operating procedures for exosome isolation and characterization, problems related to yield, and heterogeneity. In addition, the successful clinical application of exosomes requires strategies to optimize cargo, improve targeted delivery, and reduce the elimination of exosomes. In this review, we discuss the basic concept of exosomes and stem cell-derived exosomes in cardiovascular disease, and introduce current efforts to overcome the limitations and maximize the benefit of exosomes including engineered biomimetic exosomes. [BMB Reports 2022; 55(1): 30-38]
  • Publisher: 생화학분자생물학회
  • Language: Korean
  • Identifier: ISSN: 1976-6696
    EISSN: 1976-670X
  • Source: GFMER Free Medical Journals
    PubMed Central
    ROAD: Directory of Open Access Scholarly Resources
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