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Endometrial gene expression in the window of implantation is altered in obese women especially in association with polycystic ovary syndrome

Fertility and sterility, 2011-06, Vol.95 (7), p.2335-2341.e8 [Peer Reviewed Journal]

American Society for Reproductive Medicine ;2011 American Society for Reproductive Medicine ;2015 INIST-CNRS ;Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved. ;ISSN: 0015-0282 ;EISSN: 1556-5653 ;DOI: 10.1016/j.fertnstert.2011.03.021 ;PMID: 21481376 ;CODEN: FESTAS

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Title:
Endometrial gene expression in the window of implantation is altered in obese women especially in association with polycystic ovary syndrome
Author: Bellver, José, M.D ; Martínez-Conejero, José Antonio, Ph.D ; Labarta, Elena, M.D ; Alamá, Pilar, M.D ; Melo, Marco Antonio Barreto, M.D ; Remohí, José, M.D ; Pellicer, Antonio, M.D ; Horcajadas, José Antonio, Ph.D
Subjects: Adolescent ; Adult ; animal ovaries ; Biological and medical sciences ; Biopsy ; biosynthesis ; Case-Control Studies ; Cluster Analysis ; Embryo Implantation - genetics ; endometrium ; Endometrium - physiopathology ; Female ; Female genital diseases ; Fertility Agents, Female - administration & dosage ; gene expression ; Gene Expression Profiling - methods ; Gene Expression Regulation ; genes ; Gynecology. Andrology. Obstetrics ; human chorionic gonadotropin ; Humans ; immune system ; infertility ; Infertility, Female - genetics ; Infertility, Female - physiopathology ; Infertility, Female - therapy ; Internal Medicine ; Luteal Phase - genetics ; luteinizing hormone ; Medical sciences ; Metabolic diseases ; microarray ; morphogenesis ; Non tumoral diseases ; Obesity ; Obesity - complications ; Obesity - genetics ; Obesity - physiopathology ; Obstetrics and Gynecology ; Oligonucleotide Array Sequence Analysis ; Ovulation Induction - methods ; patients ; peptide receptors ; polycystic ovary syndrome ; Polycystic Ovary Syndrome - complications ; Polycystic Ovary Syndrome - genetics ; Polycystic Ovary Syndrome - physiopathology ; Principal Component Analysis ; Prospective Studies ; protein binding ; Spain ; Time Factors ; transcriptome ; window of implantation ; women ; Young Adult
Is Part Of: Fertility and sterility, 2011-06, Vol.95 (7), p.2335-2341.e8
Description: Objective To determine whether luteal phase endometrial transcriptome is altered in obese women during the window of implantation (WOI), considering the presence of infertility, fat distribution and association with polycystic ovary syndrome (PCOS). Design Prospective study. Setting University-affiliated infertility clinic, between May 2007 and March 2009. Patient(s) One control group of women with normal weight (n = 4), and four study groups of obese women (n = 6 each one) according to the association with infertility, PCOS, and ovarian stimulation. Intervention(s) The endometrium was biopsied 7 days after LH surge or hCG administration in 28 women. Main Outcome Measure(s) Endometrial gene expression during the WOI. Result(s) One hundred and fifty-one genes were dysregulated in obese groups compared with controls. This dysregulation was more pronounced when infertility was associated. The biologic processes of these genes belonged mainly to development and regulation of different biological functions such as transcription and biosynthesis. The molecular functions overrepresented were transcription and peptide receptor activity. The endometrium of obese women with PCOS showed dysregulated genes related to biologic processes such as development, morphogenesis, and the immune system, as well as different molecular functions such as protein binding, binding, growth factor activity, and carboxylic acid transmembrane transporter activity. Some of these genes have been previously related to implantation and unexplained infertility. Conclusion(s) Obese women present a different endometrial gene expression than controls during the WOI, which is more pronounced when infertility or polycystic ovary syndrome are associated.
Publisher: New York, NY: Elsevier Inc
Language: English
Identifier: ISSN: 0015-0282
EISSN: 1556-5653
DOI: 10.1016/j.fertnstert.2011.03.021
PMID: 21481376
CODEN: FESTAS
Source: MEDLINE
Alma/SFX Local Collection

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Endometrial gene expression in the window of implantation is altered in obese women especially in association with polycystic ovary syndrome

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