Language:

Transplantations of frozen thawed ovarian tissue demonstrate high reproductive performance and the need to revise restrictive criteria

Fertility and sterility, 2016-08, Vol.106 (2), p.467-474 [Peer Reviewed Journal]

American Society for Reproductive Medicine ;2016 American Society for Reproductive Medicine ;Copyright © 2016 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved. ;ISSN: 0015-0282 ;EISSN: 1556-5653 ;DOI: 10.1016/j.fertnstert.2016.04.031 ;PMID: 27181924

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Transplantations of frozen thawed ovarian tissue demonstrate high reproductive performance and the need to revise restrictive criteria
Author: Meirow, Dror, M.D ; Ra'anani, Hila, M.D ; Shapira, Moran, M.D ; Brenghausen, Masha, Ph.D ; Derech Chaim, Sanaz, B.Sc ; Aviel-Ronen, Sarit, M.D., Ph.D ; Amariglio, Ninette, Ph.D ; Schiff, Eyal, M.D ; Orvieto, Raoul, M.D ; Dor, Jehoshua, M.D
Subjects: Academic Medical Centers ; Adolescent ; Adult ; Antineoplastic Agents - adverse effects ; Cryopreservation ; Cryopreserved Ovarian Tissue ; Female ; Fertility Preservation ; Fertility Preservation - adverse effects ; Fertility Preservation - methods ; Fertilization in Vitro ; Humans ; Infertility, Female - diagnosis ; Infertility, Female - etiology ; Infertility, Female - physiopathology ; Infertility, Female - therapy ; Internal Medicine ; Israel ; Live Birth ; Maternal Age ; Neoplasms - drug therapy ; Obstetrics and Gynecology ; Ovary - transplantation ; Parity ; Pregnancy ; Pregnancy Rate ; Prospective Studies ; Replantation ; Reproductive Techniques, Assisted - adverse effects ; Risk Factors ; Safety ; Survivors ; Time Factors ; Transplantation ; Treatment Outcome ; Young Adult
Is Part Of: Fertility and sterility, 2016-08, Vol.106 (2), p.467-474
Description: Objective To report the single-center results of orthotopic retransplantations of cryopreserved ovarian tissue in cancer survivors and evaluate the validity of commonly accepted procedure limitations. Design Prospective cohort study. Setting Tertiary university-affiliated assisted reproduction technology (ART) and oncology centers. Patient(s) Twenty cancer survivors who underwent ovarian transplantation of frozen-thawed ovarian tissue with the aim to conceive. Intervention(s) Ovarian tissue cryopreservation (OTCP) and transplantation, endocrine monitoring, in vitro fertilization (IVF). Main Outcome Measure(s) Endocrine profile, IVF, pregnancies, live births. Result(s) The patient ages at tissue harvesting ranged from 14 to 39 years. Fifteen women had hematologic malignancies, and two had leukemia (chronic myelogenous leukemia and acute myelogenous leukemia). Ten patients were exposed to nonsterilizing chemotherapy before OTCP. After transplantation, the endocrine recovery rate was 93%. Fourteen patients underwent IVF treatments with a fertilization rate of 58%. Sixteen pregnancies were achieved (10 after IVF, 6 spontaneous), resulting in 10 live births, two (twins) after harvesting from the mother at the age of 37. Two pregnancies are currently ongoing. After transplantation, 53% of patients conceived, and 32% delivered at least once. One patient conceived four times. Preharversting chemotherapy exposure was not associated with inferior outcomes. All patients, including two leukemia survivors, remained cancer free. Conclusion(s) Orthotopic transplantation of thawed ovarian tissue is a highly effective measure to restore fertility in sterilized cancer patients. Chemotherapy exposure before harvesting and age >35 is a realistic option in selected patients. Retransplantation in leukemic patients is possible after application of maximal safety measures. These results have led the national ethical and professional authorities to decide for the first time not to consider OTCP as an experimental modality for fertility preservation. Clinical Trial Registration Number NCT02659592.
Publisher: United States: Elsevier Inc
Language: English
Identifier: ISSN: 0015-0282
EISSN: 1556-5653
DOI: 10.1016/j.fertnstert.2016.04.031
PMID: 27181924
Source: MEDLINE
Alma/SFX Local Collection

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Transplantations of frozen thawed ovarian tissue demonstrate high reproductive performance and the need to revise restrictive criteria

American Society for Reproductive Medicine ;2016 American Society for Reproductive Medicine ;Copyright © 2016 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved. ;ISSN: 0015-0282 ;EISSN: 1556-5653 ;DOI: 10.1016/j.fertnstert.2016.04.031 ;PMID: 27181924

Searching Remote Databases, Please Wait